POU2F2 Antibody

1. Identification of novel prostate cancer drivers, ERF, CREB3L1, and POU2F2, using RegNetDriver, a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network. PMID: 28750683
2. POU2F2 regulated ROBO1 transcription, thus functionally contributing to Gastric cancer metastasis. PMID: 26019213
3. findings show that cellular factors OCT2 and HCF1 bind OriP in association with Epstein-Barr virus nuclear antigen 1 to maintain elevated histone H3K4me3 and transcriptional enhancer function PMID: 27009953
4. B-cell specific transcription factor, Oct-2, inhibits the function of the viral immediate-early protein, BZLF1, and prevents lytic viral reactivation. Oct-2 potentiates establishment of EBV latency in B cells. PMID: 22346751
5. Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma. PMID: 24435047
6. Half of the cases displayed Oct-2 expression (15/30 cases) of systemic anaplastic large-cell lymphoma measured by tissue microarray immunohistochemistry. PMID: 22158496
7. OCT-2 may act as a cell survival factor in acute myeloid leukemia by mediating expression of downstream targets, such as BCL-2. PMID: 20141429
8. Gefitinib may exert an inhibitory effect on the intracellular accumulation of drugs transported by hOCT1 and hOCT2. PMID: 20363215
9. The function of human Oct-2 in immunoglobulin(Ig)-secreting cells requires plasmacytoma-specific coativator OCA-B working synergistically to sustain the gene expression profile of the Ig-secreting cell. PMID: 14662861
10. DNase I-hypersensitive site 4 (hs4) enhancer activity in mature Burkitt's lymphoma B cells is regulated by synergistic involvement of both Oct-2 and NF-kappa B family members; Oct-2 is required for hs4 enhancer activity. PMID: 14707079
11. Alteration of the OCT2 locus does not correlate with its suppressed expression in Hodgkin lymphoma. PMID: 15796964
12. Oct-2, therefore, acts as a cell survival factor in t(14;18) lymphoma cells by directly activating the antiapoptotic gene bcl-2. PMID: 16186795
13. Oct-2, was studied in detail and found to be a bifunctional regulator: It can either repress or induce neuronal differentiation, depending on the particular isoform PMID: 19270158
14. Data suggest that OCT2 and/or OCT3 might be involved in the initial component of histamine uptake, whereas the later component of histamine uptake is likely to be mediated by another, as yet undefined uptake system(s). PMID: 19271143
15. Renal OCT2 expression is no important in the renal excretion of metformin PMID: 19536068

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HGNC: 9213

OMIM: 164176

KEGG: hsa:5452

STRING: 9606.ENSP00000431603

UniGene: Hs.147381