PRMT7 Antibody

Datasheet

Code	CSB-PA885738LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Mouse spleen tissue, Mouse lung tissue, Mouse kidney tissue, Mouse brain tissue All lanes: PRMT7 antibody at 6.2μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 79, 63, 74, 64 kDa Observed band size: 79 kDa Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA885738LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA885738LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
Citations
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PRMT7 Polyclonal antibody

Uniprot No.

Q9NVM4

Target Names

PRMT7

Alternative Names

[Myelin basic protein]-arginine N-methyltransferase PRMT7 antibody; ANM7_HUMAN antibody; FLJ10640 antibody; Histone-arginine N-methyltransferase PRMT7 antibody; KIAA1933 antibody; Myelin basic protein arginine N methyltransferase antibody; OTTHUMP00000174863 antibody; PRMT7 antibody; Protein arginine methyltransferase 7 antibody; Protein arginine N-methyltransferase 7 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Protein arginine N-methyltransferase 7 protein (285-390AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PRMT7 Antibody (Product code: CSB-PA885738LA01HU) is Non-conjugated. For PRMT7 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA885738LB01HU	PRMT7 Antibody, HRP conjugated	ELISA
FITC	CSB-PA885738LC01HU	PRMT7 Antibody, FITC conjugated
Biotin	CSB-PA885738LD01HU	PRMT7 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

PRMT7 Inhibits the Proliferation and Migration of Gastric Cancer Cells by Suppressing the PI3K/AKT Pathway via PTEN X Wang,journal of cancer,2023

Customer Reviews and Q&A

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Target Background

Function

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.

Gene References into Functions

These kinetic studies suggest a biochemical explanation for the interplay between PRMT5- and PRMT7-mediated methylation of the same substrate at different residues and also suggest a general model for regulation of PRMTs. PMID: 28874563
The authors showed that ASS1 mutations linked to type I citrullinemia disrupt the ASS1-PRMT7 interaction, which might explain the molecular pathogenesis of the disease. PMID: 28587924
Loss of PRMT7 causes decreases in arginine methylation throughout the proteome.Loss of the arginine methyltranserase PRMT7 causes syndromic intellectual disability with microcephaly and brachydactyly. PMID: 27718516
Upregulation of PRMT7 in breast cancer may have a significant role in promoting cell invasion through the regulation of MMP9. PMID: 25605249
results define PRMT7 as an inducer of breast cancer metastasis and present the opportunity for applying PRMT7-targeted therapeutics to treat highly invasive breast cancers PMID: 25136067
Data indicate that two acidic residues within the double E loop, Asp-147 and Glu-149, confer specificity to protein arginine methyltransferase 7 (PRMT7. PMID: 25294873
reducing expression of individual PRMT7 target DNA repair genes showed that only the catalytic subunit of DNA polymerase, POLD1, was able to resensitize PRMT7 knock-down cells to DNA-damaging agents. PMID: 22761421
Human protein arginine methyltransferase 7 (PRMT7) is a type III enzyme forming omega-NG-monomethylated arginine residues. PMID: 22241471
Here the authors report that H3R2 is also symmetrically dimethylated (H3R2me2s) by PRMT5 and PRMT7 and present in euchromatic regions. PMID: 22231400
both domains are required for functionality PMID: 15044439
PRMT7 (like PRMT5) is a Type II methyltransferase capable of producing symmetric dimethylarginine modifications in proteins. PMID: 15494416
that in human cells, PRMT5 and PRMT7 are required for Sm protein sDMA modification, and that Sm protein symmetric dimethylarginine modification is required for snRNP biogenesis in human cells. PMID: 17709427

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Involvement in disease

Short stature, brachydactyly, intellectual developmental disability, and seizures (SBIDDS)

Subcellular Location

Cytoplasm, cytosol. Nucleus.

Protein Families

Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family, PRMT7 subfamily

Database Links

HGNC: 25557

OMIM: 610087

KEGG: hsa:54496

STRING: 9606.ENSP00000343103

UniGene: Hs.640229

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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