PSMD11 Antibody

Datasheet

Code	CSB-PA00575A0Rb
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA00575A0Rb at dilution of 1:100 Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA00575A0Rb at dilution of 1:100 Immunofluorescence staining of MCF-7 cells with CSB-PA00575A0Rb at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PSMD11 Polyclonal antibody

Uniprot No.

O00231

Target Names

PSMD11

Alternative Names

26S proteasome non-ATPase regulatory subunit 11 antibody; 26S proteasome regulatory subunit 9 antibody; 26S proteasome regulatory subunit p44.5 antibody; 26S proteasome regulatory subunit RPN6 antibody; 26S proteasome regulatory subunit S9 antibody; MGC3844 antibody; p44.5 antibody; protease 26S, subunit, 9 antibody; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 antibody; proteasome 26S subunit, non-ATPase, 11 antibody; PSD11_HUMAN antibody; PSMD 11 antibody; PSMD11 antibody; Rpn6 antibody; S9 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human 26S proteasome non-ATPase regulatory subunit 11 protein (2-422AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PSMD11 Antibody (Product code: CSB-PA00575A0Rb) is Non-conjugated. For PSMD11 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA00575B0Rb	PSMD11 Antibody, HRP conjugated	ELISA
FITC	CSB-PA00575C0Rb	PSMD11 Antibody, FITC conjugated
Biotin	CSB-PA00575D0Rb	PSMD11 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Gene References into Functions

human embryonic stem cells (hESCs) exhibit high proteasome activity that is correlated with increased levels of the 19S proteasome subunit PSMD11 (known as RPN-6 in Caenorhabditis elegans) and a corresponding increased assembly of the 26S/30S proteasome PMID: 22972301
AMP-activated protein kinase is able to interact physically with this subunit and modify its phosphorylation status. PMID: 19616115
interaction with ubiquitinated NF-kappaB2/p100 PMID: 12185077

Subcellular Location

Nucleus. Cytoplasm, cytosol.

Protein Families

Proteasome subunit S9 family

Tissue Specificity

Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate.

Database Links

HGNC: 9556

OMIM: 604449

KEGG: hsa:5717

STRING: 9606.ENSP00000261712

UniGene: Hs.443379

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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