PSMD11 Antibody

Datasheet

Code	CSB-PA093833
Size	US$297
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Image	Western blot analysis of extracts from 293 cells and HepG2 cells, using PSMD11 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PSMD11 Polyclonal antibody

Uniprot No.

O00231

Target Names

PSMD11

Alternative Names

26S proteasome non-ATPase regulatory subunit 11 antibody; 26S proteasome regulatory subunit 9 antibody; 26S proteasome regulatory subunit p44.5 antibody; 26S proteasome regulatory subunit RPN6 antibody; 26S proteasome regulatory subunit S9 antibody; MGC3844 antibody; p44.5 antibody; protease 26S, subunit, 9 antibody; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 antibody; proteasome 26S subunit, non-ATPase, 11 antibody; PSD11_HUMAN antibody; PSMD 11 antibody; PSMD11 antibody; Rpn6 antibody; S9 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from internal of Human PSMD11.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Gene References into Functions

human embryonic stem cells (hESCs) exhibit high proteasome activity that is correlated with increased levels of the 19S proteasome subunit PSMD11 (known as RPN-6 in Caenorhabditis elegans) and a corresponding increased assembly of the 26S/30S proteasome PMID: 22972301
AMP-activated protein kinase is able to interact physically with this subunit and modify its phosphorylation status. PMID: 19616115
interaction with ubiquitinated NF-kappaB2/p100 PMID: 12185077

Subcellular Location

Nucleus. Cytoplasm, cytosol.

Protein Families

Proteasome subunit S9 family

Tissue Specificity

Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate.

Database Links

HGNC: 9556

OMIM: 604449

KEGG: hsa:5717

STRING: 9606.ENSP00000261712

UniGene: Hs.443379

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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