PSMG1 Antibody

Code CSB-PA018921LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Jurkat whole cell lysate
    All lanes: PSMG1 antibody at 2µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 33, 31 kDa
    Observed band size: 33 kDa

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA018921LA01HU at dilution of 1:100

  • Immunofluorescent analysis of PC-3 cells using CSB-PA018921LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PSMG1 Polyclonal antibody
Uniprot No.
Target Names
PSMG1
Alternative Names
PSMG1 antibody; C21LRP antibody; DSCR2 antibody; PAC1 antibody; Proteasome assembly chaperone 1 antibody; PAC-1 antibody; Chromosome 21 leucine-rich protein antibody; C21-LRP antibody; Down syndrome critical region protein 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Proteasome assembly chaperone 1 protein (91-200AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PSMG1 Antibody (Product code: CSB-PA018921LA01HU) is Non-conjugated. For PSMG1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA018921LB01HU PSMG1 Antibody, HRP conjugated ELISA
FITC CSB-PA018921LC01HU PSMG1 Antibody, FITC conjugated
Biotin CSB-PA018921LD01HU PSMG1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
Gene References into Functions
  1. RNA-seq evidence of biallelic expression of PSMG1 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of PSMG1 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals. PMID: 27100087
  2. PSMG1 mutation is associated with Crohn's disease. PMID: 22593026
  3. Data show that an additive gene-gene interaction involving TLR4, PSMG1, TNFRSF6B and IRGM was identified with CD. PMID: 21079743
  4. PSMG1 gene expression is increased in classic variant of papillary thyroid carcinoma. PMID: 21509594
  5. The DSCR2 protein is associated with the endoplasmic reticulum; it is not an integral membrane protein and it is maintained on the cytoplasmic side of the ER by indirect interaction with the ER membrane or with another protein. PMID: 15590417
  6. Further, the results of intracellular localization studies and membrane fractionation assays indicate that DSCR2 is targeted to a cytoplasmic compartment as a soluble form. PMID: 15670775
  7. two chaperones, designated proteasome assembling chaperone-1 (PAC1) and PAC2, form a heterodimer and are involved in the maturation of mammalian 20S proteasomes PMID: 16251969
  8. DSCR2 was found to interact with PPARbeta and to inhibit it. PMID: 18793612

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Subcellular Location
Cytoplasm. Endoplasmic reticulum.
Protein Families
PSMG1 family
Tissue Specificity
In the adult, detected in brain, colon, leukocytes, breast and testis. Widely expressed in the fetus. Also expressed in a variety of proliferating cell lines.
Database Links

HGNC: 3043

OMIM: 605296

KEGG: hsa:8624

STRING: 9606.ENSP00000329915

UniGene: Hs.473838

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