PTGES2 Antibody

Datasheet

Code	CSB-PA562484
Size	US$166
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Image	Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Hela cells, A549 cells, human liver cancer tissue, lncap cells, Primary antibody: CSB-PA562484(PTGES2 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
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Product Details
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Target Background

Product Details

Uniprot No.

Q9H7Z7

Target Names

PTGES2

Alternative Names

C9orf15 antibody; FLJ14038 antibody; Gamma interferon activated transcriptional element binding factor 1 antibody; GATE binding factor 1 antibody; GBF 1 antibody; GBF1 antibody; Membrane associated prostaglandin E synthase 2 antibody; MGC11289 antibody; Microsomal prostaglandin E synthase 2 antibody; mPGES 2 antibody; mPGES-2 antibody; PGES2 antibody; PGES2_HUMAN antibody; Prostaglandin E synthase 2 antibody; Prostaglandin E synthase 2 truncated form antibody; PTGES 2 antibody; PTGES2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Fusion protein of Human PTGES2

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA).

Gene References into Functions

Four single nucleotide polymorphisms in two genes in the PGE2 family, PTGES2 and PTGER4, were significantly associated with primary graft dysfunction after lung transplantation. PMID: 24467603
high immunoreactivity of mPGES-2 in pyramidal neurons of AD brains indicates that it might have a potential role in the functional replacement of cytosolic PGES or inactive mPGES-1 in later stages of Alzheimer disease PMID: 19664621
Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression PMID: 11847219
role in regulating interferon-gamma-dependent gene expression PMID: 12050152
110Cys is essential in the active site of membrane-associated prostaglandin E synthase-2 PMID: 12804604
Transactivators GBF1 and CCAAT/enhancer-binding protein-beta physically interact to induce interferon-gamma-regulated transcription; a 37-aa long peptide derived from the GBF1 protein can associate with C/EBP-beta in an IFN-inducible manner. PMID: 15879117
alphaTOS inhibits COX activity, thereby inhibiting PGE2 production in human lung epithelial cells PMID: 16714329
study obtained evidence from two Caucasian study populations that the His298-allele of PTGES2 Arg298His confers to reduced risk of type 2 diabetes PMID: 17566096
Carbonyl reductase-1 (CBR1), microsomal prostaglandin E synthase-1 and 2 (mPGES-1, mPGES-2), cytosolic prostaglandin E synthase (cPGES), aldoketoreductase (AKR1C1) and prostaglandin F synthase (AKR1C3) were all expressed in hair follicles. PMID: 17697149
risk-reducing effects of the minor His allele of the prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism could be mediated partly by lowered body mass index (BMI) PMID: 17979097
all three terminal prostaglandin synthases, mPGES-1, mPGES-2, and cPGES, are over-expressed in human gliomas PMID: 19347995
A marginal but significant influence of the PTGES2 298H single nucleotide polymorphism on BMI was found in a large population-based study. PMID: 19371221
These results indicate that mPGES-1 and mPGES-2 may each play a role in colorectal cancer progression. PMID: 19412621

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Subcellular Location

Golgi apparatus membrane; Single-pass membrane protein.; [Prostaglandin E synthase 2 truncated form]: Cytoplasm, perinuclear region.

Protein Families

GST superfamily

Tissue Specificity

Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes

Database Links

HGNC: 17822

OMIM: 608152

KEGG: hsa:80142

STRING: 9606.ENSP00000345341

UniGene: Hs.495219

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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