PYHIN1 Antibody

Code CSB-PA746957LA01HU
Size US$166
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  • Western blot
    All lanes: PYHIN1 antibody at 6µg/ml + Mouse small intestine tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 56, 55, 52, 51, 27, 26 kDa
    Observed band size: 56, 22, 84 kDa
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PYHIN1 Polyclonal antibody
Uniprot No.
Target Names
PYHIN1
Alternative Names
IFIX_HUMAN antibody; Interferon-inducible protein X antibody; Pyhin1 antibody; Pyrin and HIN domain-containing protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Pyrin and HIN domain-containing protein 1 protein (1-245AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PYHIN1 Antibody (Product code: CSB-PA746957LA01HU) is Non-conjugated. For PYHIN1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA746957LB01HU PYHIN1 Antibody, HRP conjugated ELISA
FITC CSB-PA746957LC01HU PYHIN1 Antibody, FITC conjugated
Biotin CSB-PA746957LD01HU PYHIN1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
Gene References into Functions
  1. Study demonstrates that IFIX antiviral functions work in part via viral transcriptional suppression and that HSV-1 has acquired mechanisms to block its functions via proteasome-dependent degradation. PMID: 28077445
  2. a new member of the hematopoietic interferon (IFN)-inducible nuclear protein. Six different alternatively spliced forms are transcribed from the IFIX gene PMID: 15122330
  3. IFIX alpha1 isoform functions as a tumor suppressor by repressing HDM2 function PMID: 16479015
  4. IFIXalpha suppressed the invasion activity of MDA-MB-468 breast cancer cells, and its inhibitory effect was reversed by the knockdown of maspin PMID: 18247378
Subcellular Location
[Isoform 1]: Nucleus, nucleoplasm.; [Isoform 3]: Nucleus, nucleoplasm.; [Isoform 5]: Nucleus. Nucleus speckle.
Protein Families
HIN-200 family
Tissue Specificity
Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors.
Database Links

HGNC: 28894

OMIM: 612677

KEGG: hsa:149628

STRING: 9606.ENSP00000357122

UniGene: Hs.710248

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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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