PYHIN1 Antibody, FITC conjugated

Code CSB-PA746957LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PYHIN1 Polyclonal antibody
Uniprot No.
Target Names
PYHIN1
Alternative Names
IFIX_HUMAN antibody; Interferon-inducible protein X antibody; Pyhin1 antibody; Pyrin and HIN domain-containing protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Pyrin and HIN domain-containing protein 1 protein (1-245AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
Gene References into Functions
  1. Study demonstrates that IFIX antiviral functions work in part via viral transcriptional suppression and that HSV-1 has acquired mechanisms to block its functions via proteasome-dependent degradation. PMID: 28077445
  2. a new member of the hematopoietic interferon (IFN)-inducible nuclear protein. Six different alternatively spliced forms are transcribed from the IFIX gene PMID: 15122330
  3. IFIX alpha1 isoform functions as a tumor suppressor by repressing HDM2 function PMID: 16479015
  4. IFIXalpha suppressed the invasion activity of MDA-MB-468 breast cancer cells, and its inhibitory effect was reversed by the knockdown of maspin PMID: 18247378
Subcellular Location
[Isoform 1]: Nucleus, nucleoplasm.; [Isoform 3]: Nucleus, nucleoplasm.; [Isoform 5]: Nucleus. Nucleus speckle.
Protein Families
HIN-200 family
Tissue Specificity
Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors.
Database Links

HGNC: 28894

OMIM: 612677

KEGG: hsa:149628

STRING: 9606.ENSP00000357122

UniGene: Hs.710248

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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