Phospho-FAM129A (Ser602) Antibody

Code CSB-PA589975
Size US$360
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  • Western blot analysis in vitro kinase assays were performed by mixing purified bacterially expressed WT His-Niban or the His-Niban S602A with or without purified active AKT1 using Niban (Phospho-Ser602) Antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FAM129A Polyclonal antibody
Uniprot No.
Target Names
FAM129A
Alternative Names
NIBAN1 antibody; C1orf24 antibody; FAM129A antibody; NIBAN antibody; GIG39 antibody; Protein Niban 1 antibody; Cell growth-inhibiting gene 39 protein antibody; Protein FAM129A antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Peptide sequence around phosphorylation site of serine 602 (R-A-S(p)-A-I) derived from Human Niban.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:1000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response.
Gene References into Functions
  1. Data suggest that decreasing C1orf24 protein levels by restoring microRNA miR-106b function may have therapeutic implications. PMID: 26317551
  2. DDIT3, STT3A, ARG2 and FAM129A immunohistochemistry does not appear to be useful in the diagnosis of thyroid follicular neoplasias, as they do not reliably distinguish follicular thyroid carcinoma from follicular thyroid adenoma. PMID: 22157935
  3. Gene-expression data suggest a difference in expression between STT3A, Clorf24, and TFF3 in FAs versus carcinomas that may be detected from an FNA sample. Findings must be validated from preoperative FNAs in larger numbers PMID: 21520112
  4. The expression of Niban frequently begins in the early stages of head and neck squamous carcinoma and remains upregulated throughout the carcinogenic process. Niban may be a good molecular marker of HNSCC. PMID: 19536772
  5. Niban expression is up-regulated in various types of thyroid tumors. PMID: 16949643

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Subcellular Location
Cytoplasm. Membrane; Lipid-anchor.
Protein Families
Niban family
Tissue Specificity
Expressed in various types of thyroid tumor such as papillary thyroid carcinomas and oxyphilic thyroid tumors but not in normal thyroid tissue (at protein level). Strongly expressed in heart, skeletal muscle, pancreas, white blood cells and prostate with
Database Links

HGNC: 16784

KEGG: hsa:116496

STRING: 9606.ENSP00000356481

UniGene: Hs.518662

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