RAB11B Antibody

1. Recurrent de novo mutations disturbing the GTP/GDP binding pocket of RAB11B cause intellectual disability and a distinctive brain phenotype. PMID: 29106825
2. High RAB11B expression is associated with pancreatic cancer. PMID: 27481517
3. we determined a crystal structure of the PKG II LZ-Rab11b complex. The PKG II LZ domain presents a mostly nonpolar surface onto which Rab11b docks, through van der Waals interactions PMID: 25070890
4. Upon Rab11b depletion, FGFR4 is trapped in the pericentriolar recycling compartment. PMID: 24589086
5. the predominant mechanism of melanin transfer is keratinocyte-induced exocytosis, mediated by Rab11b through remodeling of the melanosome membrane, followed by subsequent endocytosis by keratinocytes PMID: 24141907
6. Data show that the cAMP/PKA/CREB signaling pathway initiates acidosis-induced V-ATPase trafficking in salivary ducts via regulation of Rab11b expression. PMID: 22561749
7. These findings reveal a novel role for Rab11b in limiting, rather than promoting, the plasma membrane expression of Cav1.2 L-type Ca2+ channels. PMID: 21248079
8. These data introduce Rab11b as a crucial regulator and Rip11 as mediator of acidosis-induced V-ATPase traffic in duct cells of submandibular gland. PMID: 20717956
9. propose a model where Rab11B specifically transports vesicles derived from the Golgi to the immature Inner Membrane Complex of the growing daughter parasites. PMID: 20686666
10. structural analysis shows Rab11 isoforms may possess different GTP hydrolysis rates PMID: 16545962
11. This is the first report detailing apical CFTR recycling in a native expression system and to demonstrate that Rab11b regulates apical recycling in polarized epithelial cells. PMID: 19244346

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HGNC: 9761

OMIM: 604198

KEGG: hsa:9230

STRING: 9606.ENSP00000333547

UniGene: Hs.558403