RFTN1 Antibody

Code CSB-PA008331
Size US$100
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  • Western Blot analysis of 3T3 cells using Raftlin Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
RFTN1
Alternative Names
RFTN1 antibody; KIAA0084 antibody; MIG2 antibody; Raftlin antibody; Cell migration-inducing gene 2 protein antibody; Raft-linking protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the C-terminal region of Human Raftlin.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in protein trafficking via association with clathrin and AP2 complex. Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion. May regulate B-cell antigen receptor-mediated signaling. May play a pivotal role in the formation and/or maintenance of lipid rafts.
Gene References into Functions
  1. this study shows that raftlin appears to modulate cargo selection as an accessary protein of clathrin-associated adaptor protein-2 in clathrin-mediated endocytosis of TLR3/4 ligands PMID: 27022195
  2. Mitogen-inducible Gene-2 expression is reduced in breast cancer. PMID: 23645746
  3. combination of ATOH7 and RFTN1 SNPs increased risk to POAG, indicating their diversified effects in the complex genetics of glaucoma. PMID: 22222511
  4. Raftlin cooperates with the uptake receptor to mediate cell entry of poly(I:C), which is critical for activation of TLR3. PMID: 21266579
  5. These data suggest that Raftlin plays a pivotal role in the formation and/or maintenance of lipid rafts, therefore regulating B-cell antigen receptor-mediated signaling. PMID: 12805216

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Subcellular Location
Cell membrane; Lipid-anchor. Cytoplasm. Membrane raft. Endosome. Early endosome.
Protein Families
Raftlin family
Tissue Specificity
Expressed in B-cells (at protein level). Expressed in dendritic cells and macrophages.
Database Links

HGNC: 30278

KEGG: hsa:23180

STRING: 9606.ENSP00000334153

UniGene: Hs.98910

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