RGS19 Antibody

Code CSB-PA019650LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA019650LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA019650LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA019650LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RGS19 Polyclonal antibody
Uniprot No.
Target Names
RGS19
Alternative Names
G alpha interacting protein antibody; G protein signalling regulator 19 antibody; G protein; alpha-interacting protein antibody; G-alpha-interacting protein antibody; GAIP antibody; GNAI3IP antibody; Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein antibody; Regulator of G protein signalling 19 antibody; Regulator of G-protein signaling 19 antibody; RGS19 antibody; RGS19_HUMAN antibody; RGSGAIP antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Regulator of G-protein signaling 19 protein (1-87AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The RGS19 Antibody (Product code: CSB-PA019650LA01HU) is Non-conjugated. For RGS19 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA019650LB01HU RGS19 Antibody, HRP conjugated ELISA
FITC CSB-PA019650LC01HU RGS19 Antibody, FITC conjugated
Biotin CSB-PA019650LD01HU RGS19 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
Gene References into Functions
  1. RGS19 senses cellular iron availability and is stabilized under iron-depleted conditions, resulting in the induction of a growth-inhibitory signal. PMID: 26116529
  2. RGS19 may play an important role in controlling the degree of synergism between FGF-1 receptors and 5-HT1A receptors, that may work together to mediate an anti-depressant effect. PMID: 24793302
  3. Overall methylation levels in the promoter regions of three genes (ALDH1A1, OPRL1 and RGS19) are elevated in subjects who were exposed to childhood adversity. PMID: 23799031
  4. The RGS19 inhibits Ras signaling through a complex network involving a scaffold protein KSR1 and a nucleoside diphosphate kinase Nm23. PMID: 23416464
  5. elevated expression of RGS19 can severely disrupt the regulation of mitogen-activated protein kinases by small GTPases PMID: 22045062
  6. cyclin D1/3 and Cdk6 were upregulated in HEK293 cells overexpressing RGS19, while INK4A and INK4B were reduced PMID: 21705135
  7. gene structure and transcription regulation PMID: 12507475
  8. GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling PMID: 15356268

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Subcellular Location
Membrane; Lipid-anchor.
Tissue Specificity
Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
Database Links

HGNC: 13735

OMIM: 605071

KEGG: hsa:10287

STRING: 9606.ENSP00000333194

UniGene: Hs.422336

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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