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Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.
Gene References into Functions
Let-7a microRNA inhibits tumor cell growth and metastasis by directly targeting RTKN in human colon cancer. PMID: 27498032
RTKN is upregulated in hepatocellular carcinoma.MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma. PMID: 27922690
The RTKN protein is associated with lung cancer in clinic samples and exerts anticancer activity in lung adenocarcinoma cells through inhibiting cell cycle progression and the DNA replication machinery. PMID: 26935528
RTKN could affect the proliferation and metastasis of colon cancer by reducing expression of MCM2/3/5, CDK1/2 and PCNA PMID: 26349972
suggest that interaction of S100A4 and Rhotekin permits S100A4 to complex with RhoA and switch Rho function from stress fiber formation to membrane ruffling to confer an invasive phenotypea PMID: 22964635
Rho/RTKN-mediated NF-kappaB activation leading to cell survival may play a key role in gastric tumorigenesis. PMID: 15316142
overexpression may play a key role in gastric tumorigenesis by conferring cells resistance to apoptosis PMID: 15480428
These results suggest that the RTKN gene is involved in bladder carcinogenesis and progression in bladder carcinoma, indicating that RTKN gene could be a molecular target in cancer therapy. PMID: 15599595
Lin-7B is a binding partner for Rhotekin in the human brain cDNA library PMID: 16979770
SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling PMID: 17546647
Rhotekin forms a complex with vinexin and may play a role at focal adhesions. PMID: 19294487
Loss of miR-145 may provide a selective growth advantage for MCF-7 by targeting RTKN. PMID: 19360360
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Tissue Specificity
Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta, small intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and thymus. Weakly expressed in all normal cell lines tested