RTKN Antibody

Code CSB-PA020565ESR2HU
Size US$166
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  • Western blot
    All lanes: RTKN antibody at 4.66μg/ml
    Lane 1: A431 whole cell lysate
    Lane 2: HepG2 whole cell lysate
    Lane 3: MCF-7 whole cell lysate
    Lane 4: Mouse brain tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 63, 62, 57 kDa
    Observed band size: 63 kDa

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA020565ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA020565ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RTKN Polyclonal antibody
Uniprot No.
Target Names
RTKN
Alternative Names
Rhotekin antibody; Rtkn antibody; RTKN_HUMAN antibody; RTKN1 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Rhotekin protein (304-563AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures.
Gene References into Functions
  1. Let-7a microRNA inhibits tumor cell growth and metastasis by directly targeting RTKN in human colon cancer. PMID: 27498032
  2. RTKN is upregulated in hepatocellular carcinoma.MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma. PMID: 27922690
  3. The RTKN protein is associated with lung cancer in clinic samples and exerts anticancer activity in lung adenocarcinoma cells through inhibiting cell cycle progression and the DNA replication machinery. PMID: 26935528
  4. RTKN could affect the proliferation and metastasis of colon cancer by reducing expression of MCM2/3/5, CDK1/2 and PCNA PMID: 26349972
  5. suggest that interaction of S100A4 and Rhotekin permits S100A4 to complex with RhoA and switch Rho function from stress fiber formation to membrane ruffling to confer an invasive phenotypea PMID: 22964635
  6. Rho/RTKN-mediated NF-kappaB activation leading to cell survival may play a key role in gastric tumorigenesis. PMID: 15316142
  7. overexpression may play a key role in gastric tumorigenesis by conferring cells resistance to apoptosis PMID: 15480428
  8. These results suggest that the RTKN gene is involved in bladder carcinogenesis and progression in bladder carcinoma, indicating that RTKN gene could be a molecular target in cancer therapy. PMID: 15599595
  9. Lin-7B is a binding partner for Rhotekin in the human brain cDNA library PMID: 16979770
  10. SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling PMID: 17546647
  11. Rhotekin forms a complex with vinexin and may play a role at focal adhesions. PMID: 19294487
  12. Loss of miR-145 may provide a selective growth advantage for MCF-7 by targeting RTKN. PMID: 19360360

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Tissue Specificity
Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta, small intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and thymus. Weakly expressed in all normal cell lines tested
Database Links

HGNC: 10466

OMIM: 602288

KEGG: hsa:6242

STRING: 9606.ENSP00000272430

UniGene: Hs.192854

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