S100A14 Antibody

Code CSB-PA875728ESR1HU
Size US$166
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  • Western blot
    All lanes: S100A14 antibody at 4.11µg/ml + A431 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 12 kDa
    Observed band size: 12 kDa

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA875728ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA875728ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) S100A14 Polyclonal antibody
Uniprot No.
Target Names
S100A14
Alternative Names
BCMP84 antibody; Protein S100-A14 antibody; S100 calcium binding protein A14 antibody; S100 calcium-binding protein A14 antibody; S100a14 antibody; S100A15 antibody; S10AE_HUMAN antibody; S114 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Protein S100-A14 protein (1-104AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.
Gene References into Functions
  1. S100A14 is expressed in a subset of lung adenocarcinoma, and its expression is related to certain clinicopathological parameters. Furthermore, S100A14 expression was strongly correlated with migration and invasion in lung adenocarcinoma cells. PMID: 28950283
  2. Increased S100A15 expression and decreased DNA methylation of its gene promoter region were associated with high metastasis potential and poor outcome in lung adenocarcinoma. PMID: 28498804
  3. results indicate that S100A14 may have a role in the induction of differentiation and inhibition of cell metastasis in gastric cancer. PMID: 28726786
  4. We identified a two-gene signature including KCNN4 and S100A14 which was related to recurrence in optimally debulked serous ovarian carcinoma patients PMID: 27270322
  5. Co-expression of S100A14 and S100A16 correlates with a poor prognosis in human breast cancer and promotes cancer cell invasion PMID: 25884418
  6. The antimicrobial peptides psoriasin (S100A7) and koebnerisin (S100A15) suppress extracellular matrix production and proliferation of human fibroblasts PMID: 25502330
  7. S100A14 is expressed in epithelial-like, but not in mesenchymal-like, triple-negative breast cancer cells in vitro. PMID: 25912829
  8. Data show that the genetic variant 425G>A on the 5'-UTR of calcium-binding protein S100A14 was associated with reduced S100A14 expression in gastric cancer (GC) cells. PMID: 25266115
  9. Data indicate that S100A14 has a crucial role in EOC progression, and its overexpression is associated with poor prognosis. PMID: 24939856
  10. Data demonstrate that S100A14 is transcriptionally regulated by JunB and involved in esophageal squamous cell carcinoma cell differentiation. PMID: 24107296
  11. S100A14 interacts with S100A16 and regulates its expression in human cancer cells. PMID: 24086685
  12. Data show that S100A14 and HER2 are colocalized in plasma membrane of breast cancer tissue cells and breast cancer cell lines. PMID: 24285542
  13. High S100A14 expression is associated with metastasis of hepatocellular carcinoma. PMID: 23886191
  14. The solution structure of homodimeric S100A14 in the apo state solved by NMR PMID: 23197251
  15. that S100A14 promotes cell motility and invasiveness by regulating the expression and function of MMP2 in a p53-dependent manner. PMID: 22451655
  16. S100A14 provides a novel role in oral squamous cell carcinoma cell proliferation by inducing G1-arrest PMID: 22032898
  17. S100A14 induces cell apoptosis is partially in a RAGE-dependent manner PMID: 21559403
  18. S100A14 and S100A4 have roles in metastasis in colorectal cancer after surgery PMID: 19956863
  19. Data constitute strong evidence in support of the notion that S100A14 might function as a cancer suppressor working in the P53 pathway and play a role in esophageal carcinogenesis. PMID: 19351828

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Subcellular Location
Cytoplasm.
Protein Families
S-100 family
Tissue Specificity
Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes.
Database Links

HGNC: 18901

OMIM: 607986

KEGG: hsa:57402

STRING: 9606.ENSP00000340463

UniGene: Hs.288998

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