Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SCYL1 Polyclonal antibody

Uniprot No.

Q96KG9

Target Names

SCYL1

Alternative Names

Coated vesicle associated kinase of 90 kDa antibody; Coated vesicle-associated kinase of 90 kDa antibody; CVAK90 antibody; GKLP antibody; HT019 antibody; Likely ortholog of mouse N terminal kinase like protein antibody; MGC78454 antibody; N terminal kinase like antibody; N terminal kinase like protein antibody; N-terminal kinase-like protein antibody; NKTL antibody; NTKL antibody; NTKL_HUMAN antibody; NTKLBP1 antibody; P105 antibody; SCY L1 antibody; SCY1 like 1 antibody; SCY1 like 1 protein 1 antibody; SCY1-like protein 1 antibody; SCYL 1 antibody; Scyl1 antibody; SCYL1BP1 antibody; TAPK antibody; TEIF antibody; Telomerase regulation associated protein antibody; Telomerase regulation-associated protein antibody; Telomerase transcriptional element interacting factor antibody; Telomerase transcriptional element-interacting factor antibody; Teratoma associated tyrosine kinase antibody; Teratoma-associated tyrosine kinase antibody; TRAP antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human N-terminal kinase-like protein (460-740AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro.; Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.

Gene References into Functions

findings indicate that SCYL1 does not contribute to REST turnover and thus do not support a previous study suggesting a role for SCYL1 in mediating REST degradation PMID: 28570664
Disruptive SCYL1 mutations underlie a syndrome characterized by recurrent episodes of liver failure, peripheral neuropathy, cerebellar atrophy, and ataxia. PMID: 26581903
Data identified the large GTPase dynamin2 as an interacting protein of NTKL, which might be responsible for the phenotype alterations caused by NTKL overexpression, such as cytokinesis failure, increased cell motility and abnormal of cell division. PMID: 25575811
Data reveal that Scyl1 is a key organizer of a subset of the COPI machinery. PMID: 24481816
TEIF is a downstream effector in EGF/PI3K/Akt signaling. PMID: 24769208
TEIF as a novel MSP58-interacting protein. PMID: 24361335
suggested that the interaction of SCYL1BP1/Pirh2 could accelerate Pirh2 degradation through an ubiquitin-dependent pathway. SCYL1BP1 may function as an important tumor suppressor gene in HCC development PMID: 22570270
TEIF protein and centrosome amplification is commonly found in colorectal tumors. The expression level of TEIF is related to tumor histological grade and malignant degree. PMID: 19958622
Scyl1 interacts with 58K/formiminotransferase cyclodeaminase (FTCD) and golgin p115, and is required for the maintenance of Golgi morphology PMID: 20209057
Scyl1 participates in the nuclear aminoacylation-dependent tRNA export pathway. PMID: 20505071
SCYL1-BP1 can be ubiquitinated and degraded by Pirh2 but not by MDM2, which suggests that SCYL1-BP1 can be regulated by Pirh2. PMID: 20598683
NTKL is involved in centrosome-related cellular functions PMID: 12036289
Molecular cloning of telomerase transcriptional elements-interacting factor,(TEIF). TEIF may take part in the transcriptional activation of hTERT. PMID: 15504359
TEIF could specifically activate transcription of beta-pol promoter, but not that of DNA polymerase alpha or delta promoter. The responsible sequences for binding of TEIF were revealed PMID: 15963946
TEIF functions as a centrosome regulator. Its participation in DNA damage response, including telomere dysfunction and tumorigenesis. PMID: 19198626

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Involvement in disease

Spinocerebellar ataxia, autosomal recessive, 21 (SCAR21)

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner.; [Isoform 1]: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.; [Isoform 2]: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.; [Isoform 3]: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner.; [Isoform 6]: Nucleus.

Protein Families

Protein kinase superfamily

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 14372

OMIM: 607982

KEGG: hsa:57410

STRING: 9606.ENSP00000270176

UniGene: Hs.238839

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Code	CSB-PA839356DSR2HU
Size	US$166
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Image	Western blot All lanes: SCYL1 antibody at 3.15 μg/ml Lane 1: 293T whole cell lysate Lane 2: Hela whole cell lysate Lane 3: 3T3 whole cell lysate Lane 4: A549 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 90, 89, 79, 87, 70 kDa Observed band size: 90, 110 kDa
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SCYL1 Antibody

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Target Background