SF3B3 Antibody

Code CSB-PA614890ESR2HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA614890ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA614890ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SF3B3 Polyclonal antibody
Uniprot No.
Target Names
SF3B3
Alternative Names
KIAA0017 antibody; Pre mRNA splicing factor SF3b 130 kDa subunit antibody; Pre-mRNA-splicing factor SF3b 130 kDa subunit antibody; RSE1 antibody; SAP 130 antibody; SAP130 antibody; SF3b130 antibody; SF3B3 antibody; SF3B3_HUMAN antibody; Spliceosome associated protein 130 antibody; Spliceosome-associated protein 130 antibody; Splicing factor 3b subunit 3 130kD antibody; Splicing factor 3B subunit 3 antibody; STAF130 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Splicing factor 3B subunit 3 protein (948-1217AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Gene References into Functions
  1. These results suggest SF3B3 as a key regulator of EZH2 pre-mRNA splicing and SF3B3 may represent a novel prognostic factor and potential therapeutic target in clear cell renal cell carcinoma PMID: 27879367
  2. our findings suggest a role for the elevated expression of SF3B3 in poor prognosis and tamoxifen resistance, leading to recurrence of estrogen receptor-positive breast cancer PMID: 25431237
  3. Report detection of SF3B3 gene mutations in oral cancer using high resolution melting analysis. PMID: 25651737
Subcellular Location
Nucleus.
Protein Families
RSE1 family
Database Links

HGNC: 10770

OMIM: 605592

KEGG: hsa:23450

STRING: 9606.ENSP00000305790

UniGene: Hs.514435

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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