SFXN4 Antibody

Code CSB-PA744046LA01HU
Size US$166
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  • Western blot
    All lanes: SFXN4 antibody at 0.3µg/ml
    Lane 1: K562 whole cell lysate
    Lane 2: U251 whole cell lysate
    Lane 3: U87 whole cell lysate
    Lane 4: A549 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 38, 35, 25 kDa
    Observed band size: 38 kDa

  • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA744046LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA744046LA01HU at dilution of 1:100

  • Immunofluorescent analysis of U251 cells using CSB-PA744046LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SFXN4 Polyclonal antibody
Uniprot No.
Target Names
SFXN4
Alternative Names
SFXN4; BCRM1; Sideroflexin-4; Breast cancer resistance marker 1
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Sideroflexin-4 protein (2-110AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SFXN4 Antibody (Product code: CSB-PA744046LA01HU) is Non-conjugated. For SFXN4 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA744046LB01HU SFXN4 Antibody, HRP conjugated ELISA
FITC CSB-PA744046LC01HU SFXN4 Antibody, FITC conjugated
Biotin CSB-PA744046LD01HU SFXN4 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description
SFXN4 polyclonal antibody CSB-PA744046LA01HU was produced in rabbit immunized by using the Recombinant Human Sideroflexin-4 protein (2-110AA) as the immunogen. The target protein SFXN4 a member of the sideroflexin family, is a transmembrane protein of the inner mitochondrial membrane, and is required for mitochondrial respiratory homeostasis and erythropoiesis. It is not able to mediate transport of serine into mitochondria. Diseases associated with SFXN4 include Combined Oxidative Phosphorylation Deficiency 18 and Macrocytic Anemia.
This Rabbit anti-Homo sapiens (Human) SFXN4 Polyclonal antibody was tested in the ELISA, IHC, IF and WB applications. The non-conjugated IgG was purified by antigen affinity. It only reacts with the SFXN4 proteins of human origin and may be used to detect the endogenous levels of SFXN4 protein.

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Target Background

Function
Mitochondrial amino-acid transporter. Does not act as a serine transporter: not able to mediate transport of serine into mitochondria.
Gene References into Functions
  1. Our findings establish mutations in SFXN4 as a cause of mitochondriopathy and macrocytic anemia. PMID: 24119684
  2. we isolated a cDNA encoding a novel sideroflexin protein (SFXN4), which showed 59% identity and 71% similarity to mouse sideroflexin4. PMID: 14756423
Involvement in disease
Combined oxidative phosphorylation deficiency 18 (COXPD18)
Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein Families
Sideroflexin family
Database Links

HGNC: 16088

OMIM: 615564

KEGG: hsa:119559

STRING: 9606.ENSP00000347924

UniGene: Hs.655168

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