SHB Antibody

Datasheet

Code	CSB-PA050052
Size	US$119
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Target Background

Product Details

Uniprot No.

Q15464

Target Names

SHB

Alternative Names

bA3J10.2 antibody; OTTHUMP00000021397 antibody; RP11 3J10.8 antibody; RP113J10.8 antibody; SH2 domain containing adapter protein B antibody; SH2 domain-containing adapter protein B antibody; SHB (Src homology 2 domain containing) adaptor protein B antibody; SHB adaptor protein (a Src homology 2 protein) antibody; SHB adaptor protein antibody; Shb antibody; SHB_HUMAN antibody; Src homology 2 domain containing adaptor protein B antibody; Src homology 2 protein antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from the C-terminal region of Human Shb.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:5000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.

Gene References into Functions

This article provides a resource for the available molecular tools that can be used in future research on Shb PMID: 29194461
It is concluded that tumor SHB gene expression relates to acute myeloid leukemia survival PMID: 28982308
SHB plays a role in integrating adaptive responses to various stimuli by simultaneously modulating cellular responses in different cell-types. [review] PMID: 26489764
SH2-Bbeta is a Rac-binding protein that regulates cell motility PMID: 11786545
Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells (SLP-76) PMID: 12084069
SHB links IL2 receptor for signal transduction and mediates apoptosis PMID: 12200137
Taken together, our results suggest that SH2-Bbeta is a new signaling molecule involved in GDNF-induced neurite outgrowth. PMID: 16569669
It is concluded that SHB and angiogenic factors promote the development of cells expressing PDX-1 and insulin in EBs and that such cells can be separated by FACS. PMID: 16630561

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Subcellular Location

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.

Tissue Specificity

Widely expressed.

Database Links

HGNC: 10838

OMIM: 600314

KEGG: hsa:6461

STRING: 9606.ENSP00000366936

UniGene: Hs.521482

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Email: [email protected]
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Protein Service

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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