Phospho-SHB (Y246) Antibody

Code CSB-PA000618
Size US$100
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  • Western Blot analysis of 293 cells using Phospho-Shb (Y246) Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
SHB
Alternative Names
bA3J10.2 antibody; OTTHUMP00000021397 antibody; RP11 3J10.8 antibody; RP113J10.8 antibody; SH2 domain containing adapter protein B antibody; SH2 domain-containing adapter protein B antibody; SHB (Src homology 2 domain containing) adaptor protein B antibody; SHB adaptor protein (a Src homology 2 protein) antibody; SHB adaptor protein antibody; Shb antibody; SHB_HUMAN antibody; Src homology 2 domain containing adaptor protein B antibody; Src homology 2 protein antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from Human Shb around the phosphorylation site of Y246.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Gene References into Functions
  1. This article provides a resource for the available molecular tools that can be used in future research on Shb PMID: 29194461
  2. It is concluded that tumor SHB gene expression relates to acute myeloid leukemia survival PMID: 28982308
  3. SHB plays a role in integrating adaptive responses to various stimuli by simultaneously modulating cellular responses in different cell-types. [review] PMID: 26489764
  4. SH2-Bbeta is a Rac-binding protein that regulates cell motility PMID: 11786545
  5. Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells (SLP-76) PMID: 12084069
  6. SHB links IL2 receptor for signal transduction and mediates apoptosis PMID: 12200137
  7. Taken together, our results suggest that SH2-Bbeta is a new signaling molecule involved in GDNF-induced neurite outgrowth. PMID: 16569669
  8. It is concluded that SHB and angiogenic factors promote the development of cells expressing PDX-1 and insulin in EBs and that such cells can be separated by FACS. PMID: 16630561

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Subcellular Location
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.
Tissue Specificity
Widely expressed.
Database Links

HGNC: 10838

OMIM: 600314

KEGG: hsa:6461

STRING: 9606.ENSP00000366936

UniGene: Hs.521482

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