SHROOM3 Antibody

Datasheet

Code	CSB-PA844740LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA844740LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA844740LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SHROOM3 Polyclonal antibody

Uniprot No.

Q8TF72

Target Names

SHROOM3

Alternative Names

APXL3 antibody; hShrmL antibody; MSTP013 antibody; Protein Shroom3 antibody; Shrm antibody; Shrm3 antibody; SHRM3_HUMAN antibody; ShrmL antibody; Shroom family member 3 antibody; Shroom-related protein antibody; shroom3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein Shroom3 protein (1309-1571AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SHROOM3 Antibody (Product code: CSB-PA844740LA01HU) is Non-conjugated. For SHROOM3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA844740LB01HU	SHROOM3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA844740LC01HU	SHROOM3 Antibody, FITC conjugated
Biotin	CSB-PA844740LD01HU	SHROOM3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays.

Gene References into Functions

Two protein-truncating de novo mutations in two independent cases in SHROOM3 strongly implicates this protein in severe human neural tube defects. PMID: 25805808
variants disrupting the actin-binding domain of SHROOM3 may cause podocyte effacement and impairment of the glomerular filtration barrier PMID: 25273069
The SNP rs17319721 functions as a cis-acting expression quantitative trait locus of SHROOM3 that facilitates TGF-B1 signaling and contributes to allograft injury. PMID: 25437874
RESULTS: rs1260326 in GCKR (beta=1.30, P = 3.23E-03), rs17319721 in SHROOM3 (beta = -1.28, P-value = 3.18E-03) and rs12917707 in UMOD (beta = 2.0, P-value = 8.84E-04) were significantly associated with baseline estimated GFR PMID: 23586973
A recessive missense mutation in SHROOM3 is associated with heterotaxy syndrome. PMID: 21936905

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Subcellular Location

Cell junction, adherens junction. Cytoplasm, cytoskeleton. Apical cell membrane; Peripheral membrane protein.

Protein Families

Shroom family

Database Links

HGNC: 30422

OMIM: 604570

KEGG: hsa:57619

STRING: 9606.ENSP00000296043

UniGene: Hs.683808

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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