SIX6 Antibody

1. The results suggest that SIX6 influences different stages of RGC differentiation and their survival; therefore, alteration in SIX6 function due to the risk allele may lead to cellular and molecular abnormalities. PMID: 28792678
2. We replicated the association of SNP rs10483727 in the SIX1/SIX6 locus with POAG in a Saudi cohort, suggesting its role in increasing susceptibility to Primary Open Angle Glaucoma . PMID: 29190129
3. Among 8 SNPs in 3 loci that showed at least nominal association (P < 5.00E-02) in the primary cohort, a representative SNP for each loci (rs2157719 for CDKN2B-AS1, rs33912345 for SIX6, and rs9913911 for GAS7) were selected PMID: 29261660
4. elevated expressions of SIX2, SIX4, and SIX6 predicted poor overall survival (OS) in NSCLC and poor relapse-free survival (RFS) in lung adenocarcinoma PMID: 27821176
5. study replicated the association of POAG with two SNPs at the SIX1-SIX6 locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG in patients aged above 40 years PMID: 27260188
6. Six1 regulates p53 via a dual mechanism involving upregulation of microRNA-27a and downregulation of RPL26. PMID: 26687066
7. Single nucleotide polymorphism in SIX6 gene is associated with primary open angle glaucoma. PMID: 25798827
8. SIX6 and/or intraocular pressure promotes primary open-angle glaucoma by directly increasing p16INK4a expression. PMID: 26365380
9. we report a homozygous missense mutation of SIX6 associated with a unique eye phenotype characterized by optic disc anomalies, macular atrophy, and coloboma of the iris and chorioretina. PMID: 24702266
10. Nonglaucomatous individuals with the SIX6 missense variant have reduced RNFL thickness in regions known to be particularly affected in those with glaucoma. PMID: 25537207
11. Our results, in combination with previous SIX6 work, lead us to hypothesize that SIX6 risk variants disrupt the development of the neural retina, leading to a reduced number of retinal ganglion cells. PMID: 24875647
12. Our findings in humans and zebrafish suggest a functional involvement of six6b in early eye development, and open new insights into the genetic architecture of POAG. PMID: 24150847
13. No evidence was found that SIX6 mutations underlie human congenital structural eye malformations. PMID: 15505031
14. Six6 and Six2 differ in their DNA-binding mechanisms and in the consequences of their interaction with protein tyrosine phosphatase Eyes Absent in Six2/6-DNA-binding ability. PMID: 18293925
15. BOR and OAVS features are associated with duplication of SIX1, SIX6 and OTX2 resulting from a complex chromosomal rearrangement. PMID: 18666230

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HGNC: 10892

OMIM: 212550

KEGG: hsa:4990

STRING: 9606.ENSP00000328596

UniGene: Hs.194756