SLC20A1 Antibody

1. Targeted sequencing of two candidate genes, SLC20A1 and SLC15A4, of the solute carrier membrane transport protein family in 200 additional patients demonstrated two further variants predicted as damaging for combined hormone deficiency. PMID: 29261175
2. Overexpression of SLC20A1 is associated with Estrogen Receptor-positive Breast Cancer. PMID: 27986439
3. indoxyl sulfate promotes Pit-1 expression in part by activation of the JNK pathway in vascular smooth muscle cells PMID: 27001263
4. Ox-LDL induces an osteogenic change in human aortic valve interstitial cells marked by the induction of PiT-1. PMID: 23849774
5. Overexpression of SLC20A1 promotes apoptosis and mineralization by altering the level of Akt-1. PMID: 23308213
6. Allelic variations in SLC20A1 were associated with the levels of Sodium-lithium countertransport. PMID: 21796222
7. the human PiT2 histidine, H(502), and the human PiT1 glutamate, E(70),--both conserved in eukaryotic PiT family members--are critical for P(i) transport function PMID: 21586110
8. Identification of a novel transport-independent function of PiT1/SLC20A1 in the regulation of TNF-induced apoptosis. PMID: 20817733
9. propose that region A of Pit1 confers competence for viral entry by influencing the topology of the authentic binding site in the membrane and hence its accessibility to a viral envelope protein PMID: 12097582
10. Two highly conserved glutamate residues critical for sodium-dependent phosphate transport are revealed by uncoupling transport function from retroviral receptor function. PMID: 12205090
11. Our results link low-grade IL-8-mediated cartilaginous inflammation in OA to altered chondrocyte differentiation and disease progression through PiT-1 expression and sodium-dependent Pi uptake mediated by CXCR1 signaling. PMID: 15641067
12. Phosphate uptake through Pit-1 is essential for vascular smooth muscle cell calcification and phenotypic modulation in response to elevated phosphate. PMID: 16527991
13. Results describe the characterization of transport mechanisms and determinants critical for sodium-dependent phosphate symport of the PiT family paralogs human PiT1 and PiT2. PMID: 16790504
14. Analysis of kinetics and substrate specificity of SLC20A1. PMID: 17494632
15. An overexpression of Pit-1 seems to play a key role in the formation of soft tissue calcification in Werner syndrome. PMID: 18729813
16. PiT1 depletion markedly reduces cell proliferation, delays cell cycle, and impairs mitosis and cytokinesis. PMID: 19726692

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HGNC: 10946

OMIM: 137570

KEGG: hsa:6574

STRING: 9606.ENSP00000272542

UniGene: Hs.187946