Product Details

Uniprot No.

Target Names

SLC22A18

Alternative Names

SLC22A18 antibody; BWR1A antibody; BWSCR1A antibody; HET antibody; IMPT1 antibody; ITM antibody; ORCTL2 antibody; SLC22A1L antibody; TSSC5 antibody; Solute carrier family 22 member 18 antibody; Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein antibody; Efflux transporter-like protein antibody; Imprinted multi-membrane-spanning polyspecific transporter-related protein 1 antibody; Organic cation transporter-like protein 2 antibody; ORCTL-2 antibody; Solute carrier family 22 member 1-like antibody; Tumor-suppressing STF cDNA 5 protein antibody; Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein antibody; p45-Beckwith-Wiedemann region 1 A antibody; p45-BWR1A antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthesized peptide derived from the C-terminal region of Human ORCTL2.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IF, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IF	1:200-1:1000
ELISA	1:10000

Protocols

Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney.

Gene References into Functions

Data provide evidence that SLC22A18 and/or CDKN1C are tumor modifier genes involved in the tumorigenesis of SDHD-mutated paraganglioma. PMID: 27402879
Establish SLC22A18 as a tumor suppressor in colon epithelial cells and propose that SLC22A18 is potentially a marker of diagnostic and prognostic values. PMID: 26196590
microRNA-137 functions as a tumor suppressor in human non-small cell lung cancer by targeting SLC22A18 PMID: 25498886
Upregulated expression of SLC22A18 enhanced the radiosensitivity of glioma U251 cells. PMID: 24481489
SLC22A18 protein expression predicted a significantly shorter overall survival in 51 patients receiving TMZ therapy, whereas no differences in overall survival were observed in 35 patients without TMZ therapy PMID: 23514245
SLC22A18 functions as a tumor suppressor in glioma and represents a candidate biomarker for long-term survival in this disease. PMID: 22153794
The expression level of SLC22A18 in non-small cell lung cancer was significantly higher than that in normal tissue. PMID: 22237119
SLC22A18 downregulation via promoter methylation is associated with the development and progression of glioma. PMID: 21936894
Low expression of SLC22A18 was associated with tumor progression, recurrence and poor survival after breast surgery PMID: 21144813
SLC22A18 gene is imprinted, with preferential expression from the maternal allele. PMID: 9751628
involved in the drug resistance mechanism of tumors PMID: 11925925
UbcH6-RING105 may define a novel ubiquitin-proteasome pathway that targets TSSC5 in mammalian cells PMID: 16314844
study reports the imprinting status of SLC22A18AS in breast tissue and breast cancer, and shows that gain of imprinting affects both the sense, and antisense transcripts at this locus PMID: 16624517
Mutational analysis of the two Sp1 sites suggested their requirement for the promoter activityof SLC22A18. PMID: 18996451
recent demonstration that the promoter of this gene is positively regulated by Sp1 PMID: 18996451

Hide All

Involvement in disease

Lung cancer (LNCR); Rhabdomyosarcoma, embryonal, 1 (RMSE1)

Subcellular Location

Apical cell membrane; Multi-pass membrane protein.

Protein Families

Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family

Tissue Specificity

Expressed at high levels in adult and fetal kidney and liver, and adult colon. Expressed in fetal renal proximal tubules (at protein level). Expressed at lower levels in heart, brain and lung.

Database Links

HGNC: 10964

OMIM: 114480

KEGG: hsa:5002

STRING: 9606.ENSP00000307859

UniGene: Hs.50868

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Code	CSB-PA003603
Size	US$119
	Order now
Image	Western Blot analysis of COLO205 cells using ORCTL2 Polyclonal Antibody
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SLC22A18 Antibody

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Target Background