SLC44A2 Antibody

1. Variants in SLC44A2 gene is associated with thrombosis. PMID: 26908601
2. SLC44A2 SNPs are associated with Meniere's disease severity. PMID: 27829169
3. Although circulating nucleosomes and elastase - alpha 1-antitrypsin complexes are at present the best characterized biomarkers for neutrophil extracellular traps formation and neutrophil activation, their lack of association with rs2288904 genotype does not exclude a role for SLC44A2 in neutrophil activation (and possibly NET formation) in Venous Thromboembolism. PMID: 27093231
4. The differential expression pattern of CTL1 and CTL2 suggests that CTL1 is the key transporter involved in choline transport from maternal circulation and both transporters are likely involved in stromal and endothelial cell choline transport. PMID: 26601765
5. The Yi population of China had the highest frequency of blood donors at risk of harboring anti-HNA-3a compared to any population PMID: 26593331
6. Study found 38 SNPs, including one novel SNP, in 8192 nucleotides covering the CDS of the SLC44A2 gene among 302 blood donors. PMID: 26437811
7. The HNA-3 incompatibility in central Thais (33.28%) was higher than northern Thais (28.75%), corresponding to a significantly higher probability of HNA-3a alloimmunization (P<0.05) similar to Japanese and Chinese populations. This study showed the high risk of HNA-3 incompatibility and alloimmunization, especially in central Thai blood donors. PMID: 25608003
8. HNA-3a (CTL2) antibodies in the pathogenesis of transfusion-related acute lung injury PMID: 25006121
9. Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism. PMID: 25772935
10. The findings show that, for binding to CTL2, Type 2 HNA-3a antibodies require nonpolymorphic amino acid residues in the third, and possibly the second, EC loops of CTL2 PMID: 24846273
11. Allele frequencies were determined in the blood donor population as follows: 0.318 for HNA-1a, 0.668 for HNA-1b, 0.014 for HNA-1c, 0.768 for HNA-3a, 0.232 for HNA-3b, 0.882 for HNA-4a, 0.118 for HNA-4b, 0.736 for HNA-5a and 0.264 for HNA-5b. PMID: 23398146
12. inherited 537T variant of CTL2 gene is located in HNA-3a allele results impaired granulocyte agglutination by four of 14 antibodies tested while 988T remains nearly unaffected. PMID: 21564101
13. HNA-3b/b genotype results for six different racial and ethnic groups showed that there could be a significant risk of producing anti-HNA-3a in Chinese, and Caucasian and Asian Indian blood donors, but low risk in Hispanic, African, or Native Americans. PMID: 22414054
14. HEK293 cells expressing full-length CTL2 proteins were useful in the detection of HNA-3 antibodies even in the presence of HLA antibodies. PMID: 22211383
15. African Americans have a significantly lower probability of possessing the SLC44A2*2 allele and may thus be less likely to form the clinically relevant anti-HNA-3a. PMID: 22040064
16. SLC44A2 P1 and P2 isoforms with differing glycosylation are variably expressed in cochlea, tongue, heart, colon, lung, kidney, liver and spleen suggesting tissue specific differences that may influence function in each tissue. PMID: 20665236
17. In conclusion, choline transport in A549 cells is increased by treatment with DEX, and the increase is mediated by induction of functional choline transporters CTL1 and CTL2. PMID: 20410607
18. Mass spectrometric analysis of proteins immunoprecipitated from leukocytes by anti-HNA-3a provided direct evidence that anti-HNA-3a recognizes choline transporter-like protein 2. PMID: 20040764
19. SNP with arginine rather than glutamine at position 154 constitutes HNA-3a antigen and risk of transfusion-related acute lung injury (TRALI) PMID: 20037594
20. CTL2 is more widely distributed than previously described, and its prominent expression on cells facing the scala media suggests a possible role in homeostasis. PMID: 17926100

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HGNC: 17292

OMIM: 606106

KEGG: hsa:57153

STRING: 9606.ENSP00000336888

UniGene: Hs.534560