SLC4A10/SLC4A8 Antibody

Datasheet

Code	CSB-PA859849
Size	US$297
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Image	Western blot analysis of extracts from COLO cells, using SLC4A8/10 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLC4A10/SLC4A8 Polyclonal antibody

Uniprot No.

Q6U841

Target Names

SLC4A10/SLC4A8

Alternative Names

NBCn 2 antibody; NBCn2 antibody; NCBE antibody; S4A10 antibody; S4A10_HUMAN antibody; SLC 4A10 antibody; SLC4 A10 antibody; SLC4A 10 antibody; Slc4a10 antibody; Sodium driven chloride bicarbonate exchanger antibody; Sodium-driven chloride bicarbonate exchanger antibody; Solute carrier family 4 member 10 antibody; Solute carrier family 4, sodium bicarbonate cotransporter like, member 10 antibody; Solute carrier family 4, sodium bicarbonate transporter like, member 10 antibody; Solute carrier family 4, sodium bicarbonate transporter, member 10 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from internal of Human SLC4A8/10.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH. Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride. Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange. Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid. Reduces the excitability of CA1 pyramidal neurons and modulates short-term synaptic plasticity. Required in retinal cells to maintain normal pH which is necessary for normal vision. In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules.

Gene References into Functions

genetic variation in SLC4A10 expression and function in the central nervous system may affect the regulation of systemic water balance PMID: 28360221
There was no association between common sequence variants in the AQP1 or SLC4A10 genes and primary open-angle glaucoma in the Caucasian population. PMID: 20101282
propose to rename NCBE as the second electroneutral Na/HCO(3) cotransporter, NBCn2 PMID: 18319254
SLC4A10 (OMIM 605556), a sodium bicarbonate transporter gene with high expression in the cerebral cortex and hippocampus, was disrupted by the translocation breakpoint on chromosome 2q24. PMID: 18413482

Subcellular Location

Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Perikaryon. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse.

Protein Families

Anion exchanger (TC 2.A.31) family

Tissue Specificity

Predominantly expressed in the brain.

Database Links

HGNC: 13811

OMIM: 605556

KEGG: hsa:57282

STRING: 9606.ENSP00000393066

UniGene: Hs.333958

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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