SNTA1 Antibody

Datasheet

Code	CSB-PA100755
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA100755(SNTA1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200) Gel: 8%SDS-PAGE, Lysate: 80 μg, Lane 1-2: Human lung cancer and placenta tissue, Primary antibody: CSB-PA100755(SNTA1 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details
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Target Background

Product Details

Uniprot No.

Q13424

Target Names

SNTA1

Alternative Names

59 kDa dystrophin-associated protein A1 acidic component 1 antibody; Acidic alpha 1 syntrophin antibody; Alpha 1 syntrophin antibody; Alpha-1-syntrophin antibody; dJ1187J4.5 antibody; Dystrophin associated protein A1 59kDa acidic component antibody; LQT12 antibody; OTTHUMP00000030650 antibody; Pro-TGF-alpha cytoplasmic domain-interacting protein 1 antibody; SNT1 antibody; Snta1 antibody; SNTA1_HUMAN antibody; Syntrophin 1 antibody; Syntrophin-1 antibody; TACIP1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human SNTA1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:25-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate.

Gene References into Functions

not associated with sudden infant death syndrome PMID: 28520217
Low SNTA expression is associated with non-alcoholic steatohepatitis but is unchanged in hepatocellular carcinoma. PMID: 28941732
A novel SNTA1 variant is likely causative for drug induced long-QT syndrome by augmenting the late sodium current. PMID: 27028743
In a nonreferred nationwide Danish cohort of SIDS cases, up to 5/66 (7.5%) of SIDS cases can be explained by genetic variants in the sodium channel complex genes. PMID: 25757662
our results present a possible mechanism of Rac1 activation involving SNTA1 and emphasise its role in ROS generation, cell migration, and acquisition of malignancy. PMID: 24434436
Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology. PMID: 24014171
alpha-Syntrophin, which resides in nuclei of myocytes, functions as the upstream mediator of nuclear nNOS translocation and nNOS-dependent mitochondrial biogenesis. PMID: 24235139
Calcium homeostasis mishandling in Duchenne muscular dystrophy myotubes depends on store operated calcium entry under the influence alpha1-syntrophin regulation as well as TRPV2-dependant cation influx. PMID: 23426965
The combined mutations of A261V-SNTA1 plus R800L-SCN5A increase the INa current late/peak ratio and time constants of current decay. PMID: 23376825
In contrast to stomach, lung, colon and rectal cancers, SNTA1 protein was found to be downregulated in esophageal cancers and upregulated in breast cancer. PMID: 21091386
alpha1D-adrenergic receptors are regulated by syntrophins through a PDZ domain-mediated interaction PMID: 16533813
These results establish an SNTA1-based nNOS complex attached to SCN5A as a key regulator of sodium current and suggest that SNTA1 be considered a rare long QT syndrome-susceptibility gene. PMID: 18591664
SNTA1 is a new susceptibility gene for LQTS. A257G-SNTA1 can cause gain-of-function of Na(v)1.5 similar to the LQT3. PMID: 19684871
Alpha1-syntrophin mutations identified in sudden infant death syndrome cause an increase in late cardiac sodium current. PMID: 20009079

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Involvement in disease

Long QT syndrome 12 (LQT12)

Subcellular Location

Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell junction. Cytoplasm, cytoskeleton.

Protein Families

Syntrophin family

Tissue Specificity

High expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney and lung. Not detected in placenta.

Database Links

HGNC: 11167

OMIM: 601017

KEGG: hsa:6640

STRING: 9606.ENSP00000217381

UniGene: Hs.31121

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Service

Phage Display Service

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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