SPRR1A Antibody

Code CSB-PA022610LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA022610LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA022610LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA022610LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SPRR1A Polyclonal antibody
Uniprot No.
Target Names
SPRR1A
Alternative Names
SPRR1A antibody; Cornifin-A antibody; 19 kDa pancornulin antibody; SPRK antibody; Small proline-rich protein IA antibody; SPR-IA antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Cornifin-A protein (8-72AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SPRR1A Antibody (Product code: CSB-PA022610LA01HU) is Non-conjugated. For SPRR1A Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA022610LB01HU SPRR1A Antibody, HRP conjugated ELISA
FITC CSB-PA022610LC01HU SPRR1A Antibody, FITC conjugated
Biotin CSB-PA022610LD01HU SPRR1A Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
Gene References into Functions
  1. mRNA levels of LELP1, SPRR1Av1, and SPRR1Av2 were significantly higher in the skin of patients with AD compared with the control group. PMID: 27304082
  2. the SPRR1A status might play an important role in the prognosis of postmenopausal breast carcinoma patients, especially that of progesterone receptor-positive subgroups. PMID: 25424702
  3. A expression may be useful as a prognostic factor for diffuse large B-cell lymphoma. PMID: 24886019
  4. Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. PMID: 18643845
  5. the deregulated increase in SPRR1A expression in chronic atopic skin lesions reflects an insufficient rise in SPRR transcripts, unable to compensate for the lack of LOR and thus contributing to the persistence of chronic atopic dermatitis skin lesions. PMID: 19672094

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Subcellular Location
Cytoplasm.
Protein Families
Cornifin (SPRR) family
Database Links

HGNC: 11259

OMIM: 182265

KEGG: hsa:6698

STRING: 9606.ENSP00000307340

UniGene: Hs.46320

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