SPRR2A Antibody

Datasheet

Code	CSB-PA842658LA01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SPRR2A Polyclonal antibody

Uniprot No.

P35326

Target Names

SPRR2A

Alternative Names

2 1 antibody; 2-1 antibody; Small proline rich protein 2A antibody; Small proline-rich protein 2A antibody; SPR 2A antibody; SPR-2A antibody; SPR2A_HUMAN antibody; SPRR2A antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Small proline-rich protein 2A protein (1-72AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SPRR2A Antibody (Product code: CSB-PA842658LA01HU) is Non-conjugated. For SPRR2A Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA842658LB01HU	SPRR2A Antibody, HRP conjugated	ELISA
FITC	CSB-PA842658LC01HU	SPRR2A Antibody, FITC conjugated
Biotin	CSB-PA842658LD01HU	SPRR2A Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

Gene References into Functions

SPRR2a modulates ZEB-1 signaling by way of miR-200c/141-associated epithelial mesenchyme transition through SH3-domain networks and contributes to benign and malignant wound-healing responses. PMID: 24123265
SPRR2A-associated tumor behavior was mimicked by MUC1 shRNA, which induced EMT and, like SPRR2A+ cells, showed reduced metastatic capabilities PMID: 23728799
SPRR2A functions as a suppressor of p53-dependent transcriptional activity, which otherwise might impede cellular processes needed for epithelial wound repair responses. PMID: 22731250
Small proline-rich proteins (SPRR2A) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes. PMID: 18155796

Subcellular Location

Cytoplasm.

Protein Families

Cornifin (SPRR) family

Database Links

HGNC: 11261

OMIM: 182267

KEGG: hsa:6700

STRING: 9606.ENSP00000376423

UniGene: Hs.355542

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Target Therapy

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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