Name: ST3GAL2 Antibody
Brand: CUSABIO
SKU: CSB-PA618099LA01HU

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ST3GAL2 Polyclonal antibody

Uniprot No.

Q16842

Target Names

ST3GAL2

Alternative Names

3-GalNAc-alpha-2 antibody; 3-sialyltransferase 2 antibody; 3-sialyltransferase antibody; 3-ST 2 antibody; Alpha 2 antibody; Alpha 2,3-ST antibody; Beta-galactoside alpha-2 antibody; Beta-galactoside alpha-2,3-sialyltransferase antibody; CMP N-acetylneuraminate beta galactosamide alpha 2,3 sialyltransferase antibody; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2 antibody; Gal NAc6S antibody; Gal-beta-1 antibody; Gal-NAc6S antibody; SIA4B_HUMAN antibody; sialyltransferase 4B (beta-galactosidase alpha-2,3-sialytransferase) antibody; Sialyltransferase 4B antibody; SIAT4-B antibody; SIAT4B antibody; ST3 beta-galactoside alpha-2,3-sialyltransferase 2 antibody; ST3Gal II antibody; ST3GAL2 antibody; ST3GalA.2 antibody; ST3GalII antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 protein (28-210AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ST3GAL2 Antibody (Product code: CSB-PA618099LA01HU) is Non-conjugated. For ST3GAL2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA618099LB01HU	ST3GAL2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA618099LC01HU	ST3GAL2 Antibody, FITC conjugated
Biotin	CSB-PA618099LD01HU	ST3GAL2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively. Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration. Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury. Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4. Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser.

Gene References into Functions

Data suggest that ganglioside glycosyltransferases ST3GAL5, ST8SIA1, and B4GALNT1 are S-acylated at conserved cysteine residues located close to cytoplasmic border of their transmembrane domains; ST3Gal-II is acylated at conserved cysteine residue in N-terminal cytoplasmic tail; for B4GALNT1 and ST3Gal-II, dimer formation controls their S-acylation status. PMID: 28698248
This suggests that the C-terminal domain of ST3Gal-II depends on N-glycosylation to attain an optimum conformation for proper exit from the endoplasmic reticulum PMID: 25916169
Genomic structure, expression, and transcriptional regulation of ST3GALII. PMID: 12504121
ST3Gal II is a MSGb5 (stage-specific embryonic antigen-4) synthase and its increased expression level is closely related to renal carcinogenesis PMID: 12716912

Subcellular Location

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted.

Protein Families

Glycosyltransferase 29 family

Tissue Specificity

Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta, liver and pancreas. Scarcely detectable in lung and kidney.

Database Links

HGNC: 10863

OMIM: 607188

KEGG: hsa:6483

STRING: 9606.ENSP00000345477

UniGene: Hs.368611

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ST3GAL2 Antibody

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