SYNM Antibody

1. LMOD1, SYNPO2, PDLIM7, PLN, and SYNM down-regulation reflect the altered phenotype of smooth muscle cells in vascular disease and could be early sensitive markers of SMC dedifferentiation. PMID: 27470516
2. alpha-Synemin localizes to the M-band of the sarcomere through interaction with the M10 region of titin PMID: 25447537
3. Immunohistochemistry of synemin in reactive astrocytes and Rosenthal fibers in two patients with Alexander disease. There was an abundance of GFAP-positive Rosenthal fibers and widespread reactive gliosis in the white matter and subpial regions. PMID: 23594359
4. synemin positively regulates glioblastoma cell proliferation by helping sequester PP2A away from Akt, thereby favoring Akt activation. PMID: 22337773
5. Synemin knock-down did not influence the cytoskeleton expression and organization of human Chang liver cells PMID: 21144834
6. SYNM could represent a novel putative breast tumor suppressor gene that is prone to epigenetic silencing. SYNM promoter methylation may become a useful predictive biomarker to stratify breast cancer patients' risk for tumor relapse. PMID: 20543860
7. Desmuslin expression is required for the maintenance of vascular smooth muscle phenotype. Decreased desmuslin expression may affect differentiation of VSMCs and ultimately contribute to the development of varicose veins. PMID: 20573469
8. The differences in human syncoilin and beta-synemin mRNA ratios between Duchenne muscular dystrophy and normal muscles were not statistically significant PMID: 20199207
9. The LIM domain protein zyxin was identified as an interaction partner for human synemin. PMID: 19853601
10. Genomic organization and single-nucleotide polymorphism map of desmuslin, a novel intermediate filament protein on chromosome 15q26.3. PMID: 11454237
11. Expression of the intermediate filament protein synemin in myofibrillar myopathies and other muscle diseases. PMID: 12669240
12. the default of KIAA0353 gene may play a role in the occurrence and development of varicose great saphenous vein in PDVI patients. PMID: 12887813
13. The colocalization of Synemin [syn] with vimentin, GFAP, or neurofilament supports the idea that Syn is a key cross-linking protein in morphogenesis that connects different cytoskeletal structures PMID: 14552890
14. Based on its localization and its expression pattern, beta-synemin functions as a structural protein involved in maintaining muscle integrity through its interactions with alpha-dystrobrevin, desmin, and other structural proteins. PMID: 15318345
15. synemin is associated with ruffled membranes in addition to being distributed along the intermediate filament network PMID: 15657940
16. Desmuslin is down-regulated in incompetent saphenous veins. PMID: 16476617
17. Mammalian synemin is also shown to colocalize with dystrophin within muscle cell cultures PMID: 16777071
18. The stability of DMN was analyzed under the action of low-level laser therapy. PMID: 17564317
19. alpha-synemin, but not beta-synemin, interacts with both vinculin and metavinculin PMID: 18028034
20. results revealed that synemin was modulated nearly in all human human hepatocellular carcinoma cases PMID: 18084875
21. Results suggest human alpha-synemin plays an essential role in linking the heteropolymeric intermediate filament to adherens-type junctions, such as the costameres within mammalian striated muscle cells, via its interaction with talin. PMID: 18342854

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HGNC: 24466

OMIM: 606087

KEGG: hsa:23336

STRING: 9606.ENSP00000336775

UniGene: Hs.207106