TCEA1 Antibody

Code CSB-PA023265GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
TCEA1
Alternative Names
GTF2S antibody; SII antibody; TCEA antibody; Tcea1 antibody; TCEA1_HUMAN antibody; TF2S antibody; TFIIS antibody; Transcription elongation factor A (SII) 1 antibody; Transcription elongation factor A protein 1 antibody; Transcription elongation factor A, 1 antibody; Transcription elongation factor S-II protein 1 antibody; Transcription elongation factor TFIIS.o antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human SII-TFIIS,TCEA1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
Gene References into Functions
  1. RNF20, presumably via H2Bub, selectively represses oncogenic genes by interfering with chromatin recruitment of TFIIS, a factor capable of relieving stalled RNA polymerase II. RNF20 inhibits the interaction between TFIIS and the PAF1 complex. PMID: 21596312
  2. a role for TFIIS in transcription recovery and re-establishment of the balance between hypo- and hyper-phosphorylated RNAPII after DNA damage repair PMID: 20729154
  3. Results indicate that TFIIS is not limiting for the repair of transcription-blocking DNA lesions and thus the present work does not support a role for TFIIS in TC-NER. PMID: 21070792
  4. Results provide a model of the RNA polymerase II-transcription elongation factor TFIIS complex from X-ray diffraction data to 3.8 A resolution. PMID: 12914699
  5. transcription factor IIF, hepatitis delta antigen, and stimulatory factor II control human RNA polymerase II (RNAP II) pausing and transcript cleavage PMID: 14506279
  6. TFIIS has a role in suppression of transient pausing, which is the most important contribution of TFIIS to elongation from a stall position PMID: 15351637
  7. Data shpw that SII is a major component of chromatin transcription and strongly synergizes with p300 (histone acetylation) at a step subsequent to preinitiation complex formation. PMID: 16630816
  8. PLAG1 protein is overexpressed in epithelial, myoepithelial, and mesenchymal-like tumor cells in tumors with fusions to CHCHD7 and TCEA1. PMID: 16736500

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Involvement in disease
A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1.
Subcellular Location
Nucleus.
Protein Families
TFS-II family
Database Links

HGNC: 11612

OMIM: 601425

KEGG: hsa:6917

STRING: 9606.ENSP00000428426

UniGene: Hs.491745

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