TDRD3 Antibody

Datasheet

Code	CSB-PA023357GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q9H7E2

Target Names

TDRD3

Alternative Names

4732418C03Rik antibody; 6720468N18 antibody; FLJ21007 antibody; OTTHUMP00000018485 antibody; TDRD 3 antibody; tdrd3 antibody; TDRD3_HUMAN antibody; Tudor domain containing 3 antibody; Tudor domain containing protein 3 antibody; Tudor domain-containing protein 3 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human TDRD3

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

Gene References into Functions

Structural basis of the interaction between TOP3B and the TDRD3 auxiliary factor has been reported. PMID: 28176834
Top3b proteins from several animals associate with polyribosomes, which are units of mRNA translation, whereas the Top3 homologs from E. coli and yeast lack the association. The Top3b-polyribosome association requires TDRD3, which directly interacts with Top3beta and is present in animals but not bacteria or yeast. PMID: 27257063
The binding specificity and affinity of the Tudor domains of TDRD3, SMN and SPF30 proteins were characterized quantitatively. PMID: 22363433
The TDRD3 is an effector molecule that promotes transcription by binding methylarginine marks on histone tails. PMID: 21172665
Tudor domain of TDRD3 was required for its recruitment to cytoplasmic stress granules. PMID: 18632687
propose a contribution of Tdrd3 to FMRP-mediated translational repression and suggest that the loss of the FMRP-Tdrd3 interaction caused by the I304N mutation might contribute to the pathogenesis of Fragile X syndrome PMID: 18664458

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Subcellular Location

Cytoplasm. Nucleus.

Tissue Specificity

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Database Links

HGNC: 20612

OMIM: 614392

KEGG: hsa:81550

STRING: 9606.ENSP00000440190

UniGene: Hs.525061

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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