TNNI2 Antibody

Code CSB-PA024012ESR2HU
Size US$166
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  • Western blot
    All lanes: TNNI2 antibody at 3.83μg/ml + Mouse skeletal muscle tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 21 kDa
    Observed band size: 21 kDa

  • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA024012ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA024012ESR2HU at dilution of 1:100

  • Immunoprecipitating TNNI2 in Mouse skeletal muscle tissue
    Lane 1: Rabbit control IgG instead of CSB-PA024012ESR2HU in Mouse skeletal muscle tissue. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
    Lane 2: CSB-PA024012ESR2HU (8μg) + Mouse skeletal muscle tissue (500μg)
    Lane 3: Mouse skeletal muscle tissue (10μg)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TNNI2 Polyclonal antibody
Uniprot No.
Target Names
TNNI2
Alternative Names
AMCD 2B antibody; AMCD2B antibody; DA 2B antibody; DA2B antibody; fast skeletal muscle antibody; Fast twitch skeletal muscle troponin I antibody; fast-twitch isoform antibody; FSSV antibody; fsTnI antibody; TNNI 2 antibody; Tnni2 antibody; TNNI2_HUMAN antibody; tro antibody; Troponin I antibody; Troponin I fast skeletal muscle antibody; Troponin I fast twitch 2 antibody; Troponin I fast twitch isoform antibody; Troponin I fast twitch skeletal muscle isoform antibody; Troponin I skeletal fast antibody; Troponin I type 2 (skeletal fast) antibody; Troponin I type 2 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Troponin I, fast skeletal muscle protein (1-100AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC, IP
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
IP 1:200-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Gene References into Functions
  1. Mutations in genes encoding cardiac troponin I (TNNI3) and cardiac troponin T (TNNT2) caused altered troponin protein stoichiometry in patients with dilated cardiomyopathy. TNNI3p.98trunc resulted in haploinsufficiency, increased Ca(2+) -sensitivity and reduced length-dependent activation. TNNT2p.K217del caused increased passive tension. PMID: 28436080
  2. TNNI2 gene missense mutation is associated with distal arthrogryposis type 1. PMID: 26374086
  3. report the first TNNI2 mutation in classical FSS and describe an atypical adult FSS case with only facial contractures resulting from somatic mosaicism PMID: 23850728
  4. Molecular genetic investigations revealed pathogenic mutations in MYH3, TPM2, and TNNI2 in one sporadic and 19 familial cases of distal arthrogryposis. PMID: 22519952
  5. Atrial re-expression of ssTnI during paroxysmal atrial fibrillation in patients does not seem to be part of the process of AF-associated cardiomyocyte dedifferentiation but seems to result from transient cardiomyocyte stress at the onset of AF. PMID: 15289369
  6. study found a novel TNNI2 mutation in a Chinese family with distal arthrogryposis type 2B PMID: 16802141
  7. Implantation of stable human clone expressing fast-twitch skeletal muscle troponin I in female BALB/c nude mice inhibits primary tumor growth and suggests that grafts are self-inhibitory by halting angiogenesis. PMID: 17393089
  8. These findings reveal a new function for TNNI2 as a co-activator of ERRalpha. PMID: 18331830
  9. Data found that fTnI normally associated with fast twitch skeletal muscle were present at significant levels in the thoracic aorta, and that fTnI transcripts were expressed in the smooth muscle layer of mouse blood vessels of all sizes. PMID: 18548613
  10. Gene expression revealed up-regulation of pro-angiogenic (PGF), anti-apoptotics (BAG-1, BCL-2), heart development (TNNT2, TNNC1) and extracellular matrix remodelling (MMP-2, MMP-7) genes in SM. PMID: 18805052

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Involvement in disease
Arthrogryposis, distal, 2B (DA2B)
Protein Families
Troponin I family
Database Links

HGNC: 11946

OMIM: 191043

KEGG: hsa:7136

STRING: 9606.ENSP00000252898

UniGene: Hs.523403

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