TOM1 Antibody

Datasheet

Code	CSB-PA024043LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, Mouse liver tissue All lanes: TOM1 antibody at 2.4µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 54, 49, 51 kDa Observed band size: 54 kDa Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA024043LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA024043LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TOM1 Polyclonal antibody

Uniprot No.

O60784

Target Names

TOM1

Alternative Names

TOM1 antibody; Target of Myb protein 1 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Target of Myb protein 1 protein (306-487AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TOM1 Antibody (Product code: CSB-PA024043LA01HU) is Non-conjugated. For TOM1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA024043LB01HU	TOM1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA024043LC01HU	TOM1 Antibody, FITC conjugated
Biotin	CSB-PA024043LD01HU	TOM1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May be involved in intracellular trafficking. Probable association with membranes.

Gene References into Functions

This study demonstrated that Tom1 is localized in dystrophic neurites of brain in patient with Alzheimer's disease. PMID: 27206884
Tom1 modulates binding of Tollip to phosphatidylinositol 3-phosphate via a coupled folding and binding mechanism. PMID: 26320582
candidate multiple myeloma risk locus PMID: 26007630
phosphatidylinositol 5-monophosphate (PI5P) enrichment in signaling endosomes prevents endosomal maturation through the recruitment of TOM1, and point to a new function of PI5P in regulating discrete maturation steps in the endosomal system. PMID: 25588840
It was shown that that myosin VI, in concert with Tom1, plays a crucial role in autophagy. Tom1 was identified as a myosin VI binding partner on endosomes. PMID: 23023224
TOM1 is a microRNA-126 target that may have an important role in regulating innate immune responses in the cystic fibrosis lung. PMID: 20083669
a Tom1-Tollip complex functions as a factor that links polyubiquitinated proteins to clathrin PMID: 14563850
marked recruitment of TOM1 to endosomes was observed in cells overexpressing endofin or its carboxyl-terminal fragment PMID: 14613930
Tollip and Tom1 form a complex and regulate endosomal trafficking of ubiquitinated proteins PMID: 15047686
The results suggest that TOM1 is an important molecule for membrane recruitment of clathrin, and that endofin is able to exploit this recruitment at the endosome. PMID: 15657082
A 3-marker haplotype of SNPs within TOM1 was associated with psychotic bipolar affective disorder linkage PMID: 17671966

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Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein.

Protein Families

TOM1 family

Tissue Specificity

Widely expressed. Highly expressed in skeletal muscle, heart, placenta and liver.

Database Links

HGNC: 11982

OMIM: 604700

KEGG: hsa:10043

STRING: 9606.ENSP00000413697

UniGene: Hs.474705

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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