TRMT1 Antibody

Code CSB-PA024536GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
TRMT1
Alternative Names
2)G26)dimethyltransferase antibody; 2-dimethylguanosine-26 methyltransferase antibody; FLJ20244 antibody; N(2) N(2) dimethylguanosine tRNA methyltransferase antibody; N(2)-N(2)) methyltransferase antibody; TRM 1 antibody; TRM1 tRNA methyltransferase 1 homolog antibody; TRM1_HUMAN antibody; TRMT 1 antibody; Trmt1 antibody; tRNA (guanine(26)-N(2))-dimethyltransferase antibody; tRNA 2 2 dimethylguanosine 26 methyltransferase antibody; tRNA 2 antibody; tRNA(guanine 26 N(2) N(2)) methyltransferase antibody; tRNA(guanine-26 antibody; tRNA(m(2 2)G26)dimethyltransferase antibody; tRNA(m(2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human TRMT1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Gene References into Functions
  1. Results uncover a biological role for TRMT1-catalyzed tRNA modification in redox metabolism and show that individuals with TRMT1-associated ID are likely to have major perturbations in cellular homeostasis due to the lack of m2,2G modifications. PMID: 28784718
  2. a missense variant was found in GRM1 gene, while in the second family, a frameshift alteration was identified in TRMT1, both of which were found to co-segregate with the intellectual disability. PMID: 26308914
Protein Families
Class I-like SAM-binding methyltransferase superfamily, Trm1 family
Database Links

HGNC: 25980

OMIM: 611669

KEGG: hsa:55621

STRING: 9606.ENSP00000350352

UniGene: Hs.515169

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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