USP12 Antibody

Code CSB-PA025699GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
USP12
Alternative Names
Deubiquitinating enzyme 12 antibody; OTTHUMP00000042337 antibody; UBH 1 antibody; UBH1 antibody; Ubiquitin carboxyl terminal hydrolase 12 antibody; Ubiquitin carboxyl-terminal hydrolase 12 antibody; Ubiquitin hydrolyzing enzyme 1 antibody; Ubiquitin specific peptidase 12 antibody; Ubiquitin specific processing protease 12 antibody; Ubiquitin specific protease 12 like 1 antibody; Ubiquitin thioesterase 12 antibody; Ubiquitin thiolesterase 12 antibody; Ubiquitin-hydrolyzing enzyme 1 antibody; Ubiquitin-specific-processing protease 12 antibody; UBP12_HUMAN antibody; USP 12 antibody; Usp12 antibody; USP12L1 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human USP12
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability.
Gene References into Functions
  1. Usp12 deubiquitylates and prevents lysosomal degradation of LAT and Trat1 to maintain the proximal TCR complex for the duration of signaling. PMID: 26811477
  2. Usp12 directly deubiquitinates and stabilises the Akt phosphatases PHLPP and PHLPPL resulting in decreased levels of active pAkt. PMID: 25216524
  3. our results reveal WDR48 and USP12 as novel PHLPP1 regulators and potential suppressors of tumor cell survival PMID: 24145035
  4. Usp12 acts in a pro-proliferative manner by stabilizing AR and enhancing its cellular function. PMID: 24056413
  5. The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation. PMID: 22778262

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Protein Families
Peptidase C19 family, USP12/USP46 subfamily
Database Links

HGNC: 20485

OMIM: 603091

KEGG: hsa:219333

STRING: 9606.ENSP00000282344

UniGene: Hs.42400

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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