WEE2 Antibody

Code CSB-PA026085GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
WEE2
Alternative Names
hCG_39453 antibody; WEE1 homolog 2 (S. pombe) antibody; Wee1-like protein kinase 1B antibody; Wee1-like protein kinase 2 antibody; WEE1B antibody; Wee1B kinase antibody; Wee2 antibody; WEE2_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human WEE2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
Gene References into Functions
  1. homozygous mutations in WEE2 that are responsible for fertilization failure in humans, were identified. PMID: 29606300
Subcellular Location
Nucleus.
Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily
Tissue Specificity
Expressed in oocytes (at protein level). May also be expressed in testis.
Database Links

HGNC: 19684

OMIM: 614084

KEGG: hsa:494551

STRING: 9606.ENSP00000380675

UniGene: Hs.657927

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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