ZFP91 Antibody

Datasheet

Code	CSB-PA504466
Size	US$119
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Image	Western Blot analysis of hepg2, NT28 cells using Antibody diluted at 500. Secondary antibody was diluted at 1:20000
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Product Details
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Target Background

Product Details

Uniprot No.

Q96JP5

Target Names

ZFP91

Alternative Names

ZFP91 antibody; ZNF757 antibody; FKSG11E3 ubiquitin-protein ligase ZFP91 antibody; EC 2.3.2.27 antibody; RING-type E3 ubiquitin transferase ZFP91 antibody; Zinc finger protein 757 antibody; Zinc finger protein 91 homolog antibody; Zfp-91 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide from Human protein at AA range: 401-450

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Purification Method

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB,ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-10000
ELISA	1:10000

Protocols

Western Blotting(WB) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.

Gene References into Functions

lenalidomide induces the ubiquitination and degradation of ZFP91 PMID: 28530236
Data show that NF-kappaB/p65 is required for the binding of zinc finger protein 91 (ZFP91) to the HIF-1alpha promoter and for the transcriptional activation of HIF-1alpha gene mediated by ZFP91. PMID: 27144516
ZFP91 is overexpressed in prostate cancer. PMID: 27975057
hHgher protein levels of ZFP91 in all cancer cell lines. PMID: 24272675
These data clearly indicate that ZFP91 is a key regulator in LIGHT-induced activation of non-canonical NF-kappaB pathway in LTbetaR signaling. PMID: 20804734
An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. PMID: 20682767
likely to play an important role in cell proliferation and/or anti-apoptosis, and may serve as a molecular marker for AML PMID: 12738986

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Subcellular Location

Nucleus.

Protein Families

Krueppel C2H2-type zinc-finger protein family

Tissue Specificity

Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.

Database Links

HGNC: 14983

KEGG: hsa:80829

STRING: 9606.ENSP00000339030

UniGene: Hs.524920

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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