ZP2 Antibody

Datasheet

Code	CSB-PA027120ESR1HU
Size	US$166
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Image	Western blot All lanes: ZP2 antibody at 3.06μg/ml Lane 1: 293T whole cell lysate Lane 2: Hela whole cell lysate Lane 3: Jurkat whole cell lysate Lane 4: HepG2 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 83, 82 kDa Observed band size: 83 kDa Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA027120ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA027120ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ZP2 Polyclonal antibody

Uniprot No.

Q05996

Target Names

ZP2

Alternative Names

OTTHUMP00000115849 antibody; Processed zona pellucida sperm-binding protein 2 antibody; Zona pellucida glycoprotein 2 antibody; zona pellucida glycoprotein ZP2 antibody; Zona pellucida protein A antibody; Zp-2 antibody; ZP2 antibody; ZP2_HUMAN antibody; ZPA antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Zona pellucida sperm-binding protein 2 protein (651-745AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.

Gene References into Functions

Mutations in ZP2 and ZP3 have dosage effects which can cause female infertility in humans. PMID: 28646452
ZP2(51-149) sperm-binding domain is necessary for human gamete recognition and penetration through the zona pellucida. PMID: 24934154
Studies indicate that eggs from mice lacking an ortholog of ZP2 do not contain a zona pellucida (ZP), and the mice are completely infertile due to a severely reduced number of ovulated eggs in their oviducts. PMID: 23417405
observed sequence variations in exons of ZP2 gene in women with infertility of unknown origin who exhibit abnormal zona pellucida; sperm-ovum interactions appear relatively normal in these patients [CASE REPORTS] PMID: 22889493
Of all zona pellucida (ZP) proteins, recombinant human ZPA demonstrates the highest binding activity toward acrosin PMID: 15950651
Exposure of sperm to ZP proteins promoted acrosomal exocytosis and changed motility patterns. PMID: 16407501
ZP proteins were detected in both the oocyte and the granulosa cells as early as the primordial follicle stage in the human. The detection of ZP proteins in the quiescent primordial follicle suggests that these proteins have been present since oogenesis. PMID: 18033806

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Subcellular Location

[Processed zona pellucida sperm-binding protein 2]: Zona pellucida.; Cell membrane; Single-pass type I membrane protein.

Protein Families

ZP domain family, ZPA subfamily

Tissue Specificity

Expressed in occytes(at protein level).

Database Links

HGNC: 13188

OMIM: 182888

KEGG: hsa:7783

STRING: 9606.ENSP00000219593

UniGene: Hs.73982

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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