Recombinant Human C-C motif chemokine 4 protein(CCL4) (Active)

In Stock
Code CSB-AP000851HU
Product Type Chemokine
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P13236
Lead Time 5-10 business days
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias G-26 T-lymphocyte-secreted protein, Lymphocyte activation gene 1 protein, LAG-1, MIP-1-beta1-69
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human CCR5 transfected murine BaF3 cells is less than 2.0 ng/ml, corresponding to a specific activity of >5.0x105 IU/mg.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Research Area Immunology
Source E.coli
Gene Names CCL4
Expression Region 24-92aa
Tag Info Tag-Free
Mol. Weight 7.8 kDa
Protein Description Partial of NM_207007.3
PubMed ID 2462251; 2521882; 2521353; 2247088; 2568930; 1894635; 15843566; 16625196; 15489334; 2809212; 9521068; 8525373; 10540332; 12070155; 12401480; 8134838
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Function Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Subcellular Location Secreted
Protein Families Intercrine beta (chemokine CC) family
Database Links

HGNC: 10630

OMIM: 182284

KEGG: hsa:388372

STRING: 9606.ENSP00000250151

UniGene: Hs.449862

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