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| Code | CSB-AP000851HU |
| Product Type | Chemokine |
| Size |
US$112Purchase it in Cusabio online store (only available for customers from the US) |
| Uniprot No. | P13236 |
| Lead Time | 5-10 business days |
| Image | |
| Storage Buffer | 0.2 μm filtered PBS, pH 7.4 ,lyophilized |
| Alias | G-26 T-lymphocyte-secreted protein, Lymphocyte activation gene 1 protein, LAG-1, MIP-1-beta1-69 |
| Species | Homo sapiens (Human) |
| Biological_Activity | Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human CCR5 transfected murine BaF3 cells is less than 2.0 ng/ml, corresponding to a specific activity of >5.0x105 IU/mg. |
| Purity | >97% as determined by SDS-PAGE and HPLC. |
| Endotoxin | Less than 1.0 EU/μg as determined by LAL method. |
| Sequence | APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN |
| Research Area | Immunology |
| Source | E.coli |
| Gene Names | CCL4 |
| Expression Region | 24-92aa |
| Tag Info | Tag-Free |
| Mol. Weight | 7.8 kDa |
| Protein Description | Partial of NM_207007.3 |
| PubMed ID | 2462251; 2521882; 2521353; 2247088; 2568930; 1894635; 15843566; 16625196; 15489334; 2809212; 9521068; 8525373; 10540332; 12070155; 12401480; 8134838 |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. |
| Subcellular Location | Secreted |
| Protein Families | Intercrine beta (chemokine CC) family |
| Database Links |
HGNC: 10630 OMIM: 182284 KEGG: hsa:388372 STRING: 9606.ENSP00000250151 UniGene: Hs.449862 |
CCL4 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA004797KA01HU | CCL4 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA005136 | CCL4 Antibody | Human | WB,ELISA |
| CSB-PA193639 | CCL4 Antibody | Human,Rat | ELISA,IHC |
CCL4 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA05949A0Rb | CCL4 Antibody | Human | ELISA, IHC |
| CSB-PA05949B0Rb | CCL4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA05949C0Rb | CCL4 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA05949D0Rb | CCL4 Antibody, Biotin conjugated | Human | ELISA |
CCL4 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP004797HU CSB-EP004797HU CSB-BP004797HU CSB-MP004797HU |
Recombinant Human C-C motif chemokine 4(CCL4) | Yeast E.coli Baculovirus Mammalian cell |
| CSB-AP000861HU | Recombinant Human C-C motif chemokine 4 protein(CCL4) (Active) | E.coli |
CCL4 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL004797HU | Human C-C motif chemokine 4(CCL4) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 3.9 pg/mL |
Recombinant Human T-cell antigen CD7(CD7) ,partial
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human DNA repair protein RAD51 homolog 4(RAD51D)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Regulator of G-protein signaling 10(RGS10)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Aggregatibacter actinomycetemcomitans Leukotoxin(ltxA),partial
Express system: Yeast
Species: Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans)
Recombinant Macaca fascicularis Erythropoietin(EPO)
Express system: Yeast
Species: Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
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