Recombinant Human C-C motif chemokine 4 protein(CCL4) (Active)

Code CSB-AP000851HU
Product Type Chemokine
Size Pls inquiry other sizesPurchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P13236
Image
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias G-26 T-lymphocyte-secreted protein, Lymphocyte activation gene 1 protein, LAG-1, MIP-1-beta1-69
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human CCR5 transfected murine BaF3 cells is less than 2.0 ng/ml, corresponding to a specific activity of >5.0x105 IU/mg.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN
Research Area Immunology
Source E.coli
Gene Names CCL4
Expression Region 24-92aa
Product Info Tag-Free
Mol. Weight 7.8 kDa
Protein Description Partial of NM_207007.3
PubMed ID 2462251; 2521882; 2521353; 2247088; 2568930; 1894635; 15843566; 16625196; 15489334; 2809212; 9521068; 8525373; 10540332; 12070155; 12401480; 8134838
Still Have Questions? Leave a Message or Start an on-line Chat
Function Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
Subcellular Location Secreted
Protein Families Intercrine beta (chemokine CC) family
Database Links

HGNC: 10630

OMIM: 182284

KEGG: hsa:388372

STRING: 9606.ENSP00000250151

UniGene: Hs.449862

Related Products

CCL4 Antibodies

CCL4 Antibodies for Mus musculus (Mouse)

CCL4 Antibodies for Homo sapiens (Human)

CCL4 Proteins

CCL4 Proteins for Mus musculus (Mouse)

CCL4 Proteins for Homo sapiens (Human)

CCL4 Proteins for Oryctolagus cuniculus (Rabbit)

CCL4 Proteins for Rattus norvegicus (Rat)

CCL4 Proteins for Bos taurus (Bovine)

CCL4 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

CCL4 Proteins for Sus scrofa (Pig)

CCL4 Proteins for Macaca mulatta (Rhesus macaque)

CCL4 Proteins for Gallus gallus (Chicken)

CCL4 cDNA

CCL4 cDNA for Sus scrofa (Pig)

CCL4 cDNA for Macaca mulatta (Rhesus macaque)

CCL4 cDNA for Gallus gallus (Chicken)

CCL4 cDNA for Rattus norvegicus (Rat)

CCL4 cDNA for Oryctolagus cuniculus (Rabbit)

CCL4 cDNA for Canis lupus familiaris (Dog) (Canis familiaris)

CCL4 cDNA for Homo sapiens (Human)

CCL4 cDNA for Mus musculus (Mouse)

CCL4 ELISA Kit

CCL4 ELISA Kit for Bos taurus (Bovine)

CCL4 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

CCL4 ELISA Kit for Homo sapiens (Human)

CCL4 ELISA Kit for Mus musculus (Mouse)

CCL4 ELISA Kit for Sus scrofa (Pig)

CCL4 ELISA Kit for Rattus norvegicus (Rat)

Most popular with customers

+ Show More

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.

Wait!

Join the 20,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.

Sign up now to get your $50 coupon for protein expression service!

We don't deal in spam.

Wait!

Join the 25,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.

Sign up now!

We don't deal in spam.