Recombinant Human Protein FAM19A2 protein (FAM19A2) (Active)

FAM19A2 (TAFA-2) is a brain-enriched chemokine-like cytokine implicated in neuroimmune crosstalk, and this tag-free recombinant form—covering the full mature sequence (residues 31–131)—preserves native folding critical for receptor engagement. Validated biological activity confirms that the protein significantly enhances neurite outgrowth in E16–E18 rat embryonic cortical neurons when immobilized at 6–24 μg/mL, providing a suitable basis for cell-based functional assays investigating neuronal differentiation, MAPK or other downstream signaling pathway activation, and chemotaxis studies exploring TAFA-2-mediated immune cell migration. Endotoxin levels below 1.0 EU/μg minimize LPS-driven artifacts, which aligns with standards expected in primary neuron cultures, in vivo neuroimmune models, and sensitive immune cell activation experiments. Purity exceeding 95% by SDS-PAGE, combined with this stringent endotoxin control, also supports use as a coating antigen for antibody development or as a reliable positive control in ELISA-based cytokine detection assays.