Recombinant Human C-X-C motif chemokine 17 protein (CXCL17) (Active)

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Code CSB-AP000781HU
Size $142
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Product Details

>96% as determined by SDS-PAGE.
Less than 1.0 EU/μg as determined by LAL method.
Fully biologically active when compared to standard. The ED50 as determined by its ability to induce VEGF expression using murine endothelial cells is less than 5.0 μg/ml, corresponding to a specific activity of >200 IU/mg.
Target Names
Uniprot No.
Research Area
Alternative Names
CXCL17; VCC1; UNQ473/PRO842C-X-C motif chemokine 17; 6-Cys CXCL17; Dendritic cell and monocyte chemokine-like protein; DMC; VEGF coregulated chemokine 1) [Cleaved into: 4-Cys CXCL17]
Homo sapiens (Human)
Expression Region
Complete Sequence
Mol. Weight
11.5 kDa
Protein Length
Full Length of Mature Protein
Tag Info
Lyophilized powder
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4, with 3 % Trehalose.
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
5-10 business days
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.

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Target Background

Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections. Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions.; seems exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17.
Gene References into Functions
  1. High Lymph node CXCL17 messenger RNA is associated with colon cancer. PMID: 30198422
  2. High expression of CXCL17 correlates with shorter overall survival of breast cancer patients.CXCL17 interacts with CXCR8 in breast cancer cells. PMID: 28943434
  3. CXCL17 attenuates Imiquimod -induced psoriasis-like skin inflammation by recruiting myeloid-derived suppressor cells and regulatory T cells , which may be important for regulating excessive inflammation in psoriasis skin. PMID: 28389593
  4. This article shows that GPR35 is the receptor of CXCL17. PMID: 25411203
  5. CXCL17 production correlated with adverse immune infiltration and might be an important target for anti-HCC therapies. PMID: 25303284
  6. We conclude that CXCL17 is an antimicrobial mucosal chemokine that may play a role in the pathogenesis of interstitial lung diseases PMID: 22611239
  7. these results suggest that VCC-1 is involved in cisplatin-induced apoptosis of HepG2 cells, and also provides some evidence for VCC-1 as a potential cellular target for chemotherapy. PMID: 22425983
  8. An Fc-fusion protein of 35kDa with a modified human immunoglobulin IgG1 Fc domain is capable of inhibiting CC chemokine-induced calcium flux, chemotaxis, and beta-arrestin recruitment in primary macrophages and transfected cells. PMID: 21586597
  9. Immune surveillance occurs during the early intraepithelial stages of human pancreatic carcinogenesis and is mediated by expression of CXCL17 and ICAM2. PMID: 20955708
  10. DMC induces migration of monocytes and immature dendritic cells. Expression studies show that DMC is constitutively expressed in lung, suggesting a potential role for DMC in recruiting monocytes and dendritic cells from blood into lung parenchyma PMID: 16455961
  11. VCC1 plays a role in angiogenesis and possibly in the development of tumors in some tissue types PMID: 16989774
  12. These results strongly suggest that VCC-1 plays an important role in hepatocellular carcinoma cell invasion and tumor growth. PMID: 19657564

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Subcellular Location
Protein Families
Intercrine alpha (chemokine CxC) family
Tissue Specificity
Detected in trachea, stomach, lung and skeletal muscle. Detected in intestine and in normal and asthmatic lung (at protein level). Breast tumors showed 3- to 24-fold up-regulation.
Database Links

HGNC: 19232

OMIM: 611387

KEGG: hsa:284340

STRING: 9606.ENSP00000472467

UniGene: Hs.445586

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