Name: Recombinant Mouse C-C motif chemokine 9 protein(Ccl9) (Active)
Brand: CUSABIO
SKU: CSB-AP001281MO

Product Details

Purity	>95% as determined by SDS-PAGE and HPLC.
Endotoxin	Less than 1.0 EU/μg as determined by LAL method.
Activity	Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration range of 0.1-10 ng/ml.
Target Names	Ccl9
Uniprot No.	P51670
Research Area	Immunology
Alternative Names	CCF18; Ccl9; CCL9(31-101); CCL9_MOUSE; Chemokine CC motif ligand 9; Macrophage inflammatory protein 1-gamma; Macrophage inflammatory protein-related protein 2; MIP-1-gamma; MRP-2; SCYA10; SCYA9; Small inducible cytokine A9; Small-inducible cytokine A9
Species	Mus musculus (Mouse)
Source	E.coli
Expression Region	22-122aa
Complete Sequence	QITHATETKE VQSSLKAQQG LEIEMFHMGF QDSSDCCLSY NSRIQCSRFI GYFPTSGGCT RPGIIFISKR GFQVCANPSD RRVQRCIERL EQNSQPRTYK Q
Mol. Weight	11.6 kDa
Protein Length	Full Length of Mature Protein
Tag Info	Tag-Free
Form	Lyophilized powder
Buffer	Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs	Protein FAQs
Storage Condition	Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time	5-10 business days
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA	Please contact us to get it.

Target Background

Function (From Uniprot)	Monokine with inflammatory, pyrogenic and chemokinetic properties. Circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor activates calcium release in neutrophils. It also inhibits colony formation of bone marrow myeloid immature progenitors.
Gene References into Functions	CCL9 secreted by splenic macrophages induces a CCR1dependent accumulation of MDSCs. PMID: 30365155 Results show that MIP-1g promotes tumor cell growth in vitro through the activation of NFkB pathway in colorectal tumor cells. PMID: 28108624 we report that chemokine CCL9 was highly induced in Gr-1(+)CD11b(+) immature myeloid cells and in premetastatic lung in tumor-bearing mice PMID: 26483204 Plasmid codelivery of murine CCL19 and CCL28 enhanced Ag-specific systemic and mucosal Ab responses to HIV-1 gp140, augmented balanced Th1/Th2 responses, and increased lymphocyte subsets in various lymphoid tissues. PMID: 23858028 There is protein-DNA interaction between ETV5 and Ccl9, suggesting that ETV5 might be a direct regulator of Ccl9 expression. PMID: 20799334 Results reveal the potential involvement of CCL9 and CCR1 in macrophage and microglial cells by CpG-ODNs and may help understanding the role of the chemokine/chemokine receptor pairs in macrophage/microglia under physiologic and pathologic conditions. PMID: 19883904 MRP-2 may be an important contributing factor in the development of atherosclerosis PMID: 12173416 CCL9 and its receptor CCR1 are the major chemokine and receptor species expressed by osteoclasts, CCL9 has a role in the regulation of bone resorption PMID: 12397598 An important role for CCL9 is demonstrated in the recruitment of CD11b+ dendritic cells to the dome regions of mouse Peyer's patches. PMID: 12960300 MIP-1 gamma plays an important role in the differentiation & survival of osteoclasts, & bone resorption, most likely via an autocrine pathway. PMID: 15265944 Keratinocyte-derived chemokine (KC) and MIP-2 alpha differ in their mediation of neutrophil function (apoptosis and chemotaxis) and contribution to the pathogenesis of lung injury following hemorrhage subsequent to sepsis. PMID: 15961314 BCR/ABL repressed CCL9 expression at the transcriptional level PMID: 17160016 involved in calcium mobilization and chemotaxis PMID: 11500837 Show More Hide All
Subcellular Location	Secreted
Protein Families	Intercrine beta (chemokine CC) family
Tissue Specificity	Expressed mainly in the liver, lung, and the thymus, although some expression has been detected in a wide variety of tissues except brain.
Database Links	KEGG: mmu:20308 STRING: 10090.ENSMUSP00000019266 UniGene: Mm.416125

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Code	CSB-AP001281MO
Size	$2617Purchase it in Cusabio online store (only available for customers from the US)
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Recombinant Mouse C-C motif chemokine 9 protein(Ccl9) (Active)

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