ALKAL1 Antibody

Code CSB-PA757795ZA01HU
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ALKAL1 Polyclonal antibody
Uniprot No. Q6UXT8
Target Names ALKAL1
Alternative Names ALKAL1 antibody; FAM150A antibody; UNQ9433/PRO34745ALK and LTK ligand 1 antibody; Augmentor beta antibody; AUG-beta antibody; Protein FAM150A antibody
Raised in Rabbit
Species Reactivity Homo sapiens
Immunogen Recombinant Human ALK and LTK ligand 1 (ALKAL1) (28-129)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (12-14 weeks)

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Target Background

Function
(From Uniprot)
Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly.
Gene References into Functions
  1. activation of ALK/LTK family receptors by small ALKAL proteins (FAM150, AUG) conserved in vertebrates PMID: 29317532
  2. In conclusion, these data show that ALK is robustly activated by the FAM150A/B ligands. PMID: 26418745
  3. Data show that leukocyte tyrosine kinase (LTK) ligand FAM150A (augmentor-beta; AUG-beta) is specific for LTK and only weakly binds to anaplastic lymphoma kinase (ALK). PMID: 26630010
  4. Only two related secreted factors, FAM150A and FAM150B (family with sequence similarity 150 member A and member B), stimulated LTK phosphorylation. PMID: 25331893
Subcellular Location Secreted.
Protein Families ALKAL family
Tissue Specificity Widely expressed with highest levels in thyroid and moderate levels in stomach, trachea, small intestine, prostate and brain.
Database Links

HGNC: 33775

KEGG: hsa:389658

STRING: 9606.ENSP00000351345

UniGene: Hs.527111

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