pycard Antibody

Code CSB-PA862308XA01DIL
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Product Details

Full Product Name
Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) pycard Polyclonal antibody
Uniprot No.
Target Names
pycard
Alternative Names
pycard antibody; asc antibody; asc1Apoptosis-associated speck-like protein containing a CARD antibody; PYD and CARD domain-containing protein antibody
Raised in
Rabbit
Species Reactivity
Danio rerio (Zebrafish) (Brachydanio rerio)
Immunogen
Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) pycard protein
Immunogen Species
Danio rerio (Zebrafish) (Brachydanio rerio)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa-dependent apoptosis. In innate immune response acts as an integral adapter in the assembly of NLRP1 inflammasomes which activate caspases caspa and caspb leading to processing and secretion of the proinflammatory cytokine il1b. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome.
Subcellular Location
Cytoplasm. Inflammasome.
Tissue Specificity
Expressed in the kidney, intestine and gill. Expressed at low levels in the heart.
Database Links

UniGene: Dr.8329

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