ASC Antibody

Datasheet
Code CSB-PA862308XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q9I9N6
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) ASC protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Apoptosis-associated speck-like protein containing a CARD (PYD and CARD domain-containing protein) pycard asc asc1
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names pycard
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa-dependent apoptosis. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates a caspase leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome.
Subcellular Location Cytoplasm
Database Links

UniGene: Dr.8329

Pathway Lipids and Inflammation in Atherogenesis
Necroptosis
NOD-like receptor signaling pathway

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