PYCARD Research Reagents

Apoptosis-associated speck-like protein containing a CARD is a protein in humans that is encoded by PYCARD gene. Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines.

The following PYCARD reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PYCARD Antibodies

PYCARD Antibodies for Homo sapiens (Human)

PYCARD Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

PYCARD Antibodies for Mus musculus (Mouse)

PYCARD Proteins

PYCARD Proteins for Bos taurus (Bovine)

PYCARD Proteins for Mus musculus (Mouse)

PYCARD Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

PYCARD Proteins for Homo sapiens (Human)

PYCARD ELISA Kit

PYCARD ELISA Kit for Homo sapiens (Human)

PYCARD ELISA Kit for Mus musculus (Mouse)

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