ATG3 Antibody

Code CSB-PA761343XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q6PFS7
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) ATG3 protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Ubiquitin-like-conjugating enzyme ATG3 (EC 6.3.2.-) (Autophagy-related protein 3) (APG3-like) atg3 apg3l zgc:64156
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names atg3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of atg12 to itself, atg12 conjugation to atg3 playing a role in mitochondrial homeostasis but not in autophagy. atg7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with atg3 (By similarity).
Subcellular Location Cytoplasm
Protein Families ATG3 family
Database Links

KEGG: dre:336632

STRING: 7955.ENSDARP00000041303

UniGene: Dr.1496

Pathway Autophagy

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