ATG3 Research Reagents

Ubiquitin-like-conjugating enzyme ATG3 is a protein in humans that is encoded by ATG3 gene. E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy.

The following ATG3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ATG3 Antibodies

ATG3 Antibodies for Homo sapiens (Human)

ATG3 Antibodies for Arabidopsis thaliana (Mouse-ear cress)

ATG3 Antibodies for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

ATG3 Antibodies for Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)

ATG3 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

ATG3 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

ATG3 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

ATG3 Proteins

ATG3 Proteins for Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)

ATG3 Proteins for Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)

ATG3 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

ATG3 Proteins for Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)

ATG3 Proteins for Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)

ATG3 Proteins for Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)

ATG3 Proteins for Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)

ATG3 Proteins for Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)

ATG3 Proteins for Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)

ATG3 Proteins for Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)

ATG3 Proteins for Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)

ATG3 Proteins for Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)

ATG3 Proteins for Pichia angusta (Yeast) (Hansenula polymorpha)

ATG3 Proteins for Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)

ATG3 Proteins for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

ATG3 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

ATG3 Proteins for Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)

ATG3 Proteins for Arabidopsis thaliana (Mouse-ear cress)

ATG3 Proteins for Bos taurus (Bovine)

ATG3 Proteins for Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)

ATG3 Proteins for Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

ATG3 Proteins for Dictyostelium discoideum (Slime mold)

ATG3 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

ATG3 Proteins for Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)

ATG3 Proteins for Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

ATG3 Proteins for Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)

ATG3 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)

ATG3 Proteins for Rattus norvegicus (Rat)

ATG3 Proteins for Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)

ATG3 Proteins for Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

ATG3 Proteins for Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)

ATG3 Proteins for Xenopus laevis (African clawed frog)

ATG3 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

ATG3 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

ATG3 Proteins for Mus musculus (Mouse)

ATG3 Proteins for Homo sapiens (Human)

ATG3 Background

Ubiquitin-like-conjugating enzyme ATG3 is a protein in humans that is encoded by the ATG3 gene. The ATG3 protein is an E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2, or MAP1LC3A). The ATG12-ATG5 conjugate plays the role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and the cytoplasm to vacuole transport (Cvt). Its preferred substrate is MAP1LC3A. It also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, and ATG12 conjugation to ATG3 plays a role in mitochondrial homeostasis but not in autophagy.

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