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Ubiquitin-like-conjugating enzyme ATG3 is a protein in humans that is encoded by ATG3 gene. E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy.
The following ATG3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ATG3 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA002288GA01HU | ATG3 Antibody |
Human,Mouse,Rat | ELISA,WB |
| CSB-PA002288HA01HU | ATG3 Antibody |
Human | ELISA, WB, IHC, IF |
| CSB-PA914063 | ATG3 Antibody |
Human,Mouse,Rat | ELISA,IHC |
| CSB-PA777675 | ATG3 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
ATG3 Antibodies for Arabidopsis thaliana (Mouse-ear cress)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA604512XA01DOA | ATG3 Antibody |
Arabidopsis thaliana | ELISA, WB (ensure identification of antigen) |
ATG3 Antibodies for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA765616XA01DOT | ATG3 Antibody |
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) | ELISA, WB (ensure identification of antigen) |
ATG3 Antibodies for Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA411356XA01STA | ATG3 Antibody |
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) | ELISA, WB (ensure identification of antigen) |
ATG3 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA334699XA01SVG | ATG3 Antibody |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ELISA, WB (ensure identification of antigen) |
ATG3 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA528580XA01SXV | atg3 Antibody |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | ELISA, WB (ensure identification of antigen) |
ATG3 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA761343XA01DIL | atg3 Antibody |
Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
ATG3 Proteins for Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP315668CTK CSB-EP315668CTK CSB-BP315668CTK CSB-MP315668CTK CSB-EP315668CTK-B |
Recombinant Cryptococcus neoformans var. neoformans serotype D Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP316821CTL CSB-EP316821CTL CSB-BP316821CTL CSB-MP316821CTL CSB-EP316821CTL-B |
Recombinant Cryptococcus neoformans var. neoformans serotype D Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP334699SVG CSB-EP334699SVG CSB-BP334699SVG CSB-MP334699SVG CSB-EP334699SVG-B |
Recombinant Saccharomyces cerevisiae Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP372982AVC CSB-EP372982AVC CSB-BP372982AVC CSB-MP372982AVC CSB-EP372982AVC-B |
Recombinant Aspergillus clavatus Autophagy-related protein 3(atg3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP374043NEZ CSB-EP374043NEZ CSB-BP374043NEZ CSB-MP374043NEZ CSB-EP374043NEZ-B |
Recombinant Neosartorya fischeri Autophagy-related protein 3(atg3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP385321SXM CSB-EP385321SXM CSB-BP385321SXM CSB-MP385321SXM CSB-EP385321SXM-B |
Recombinant Scheffersomyces stipitis Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP398927MTM CSB-EP398927MTM CSB-BP398927MTM CSB-MP398927MTM CSB-EP398927MTM-B |
Recombinant Meyerozyma guilliermondii Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP399235LLV CSB-EP399235LLV CSB-BP399235LLV CSB-MP399235LLV CSB-EP399235LLV-B |
Recombinant Lodderomyces elongisporus Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold) (Whetzelinia sclerotiorum)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP409809STG CSB-EP409809STG CSB-BP409809STG CSB-MP409809STG CSB-EP409809STG-B |
Recombinant Sclerotinia sclerotiorum Autophagy-related protein 3(atg3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP411356STA CSB-EP411356STA CSB-BP411356STA CSB-MP411356STA CSB-EP411356STA-B |
Recombinant Saccharomyces cerevisiae Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP413228BVD CSB-EP413228BVD CSB-BP413228BVD CSB-MP413228BVD CSB-EP413228BVD-B |
Recombinant Botryotinia fuckeliana Autophagy-related protein 3(atg3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP418358ETH CSB-EP418358ETH CSB-BP418358ETH CSB-MP418358ETH CSB-EP418358ETH-B |
Recombinant Penicillium chrysogenum Autophagy-related protein 3(atg3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Pichia angusta (Yeast) (Hansenula polymorpha)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP419059EVQ CSB-EP419059EVQ CSB-BP419059EVQ CSB-MP419059EVQ CSB-EP419059EVQ-B |
Recombinant Pichia angusta Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP419267VDW CSB-EP419267VDW CSB-BP419267VDW CSB-MP419267VDW CSB-EP419267VDW-B |
Recombinant Vanderwaltozyma polyspora Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP514955EKF CSB-EP514955EKF CSB-BP514955EKF CSB-MP514955EKF CSB-EP514955EKF-B |
Recombinant Emericella nidulans Autophagy-related protein 3(atg3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP528580SXV CSB-EP528580SXV CSB-BP528580SXV CSB-MP528580SXV CSB-EP528580SXV-B |
Recombinant Schizosaccharomyces pombe Autophagy-related protein 3(atg3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP604325EUG CSB-EP604325EUG CSB-BP604325EUG CSB-MP604325EUG CSB-EP604325EUG-B |
Recombinant Phaeosphaeria nodorum Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP604512DOA CSB-EP604512DOA CSB-BP604512DOA CSB-MP604512DOA CSB-EP604512DOA-B |
Recombinant Arabidopsis thaliana Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Bos taurus (Bovine)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP608556BO CSB-EP608556BO CSB-BP608556BO CSB-MP608556BO CSB-EP608556BO-B |
Recombinant Bovine Ubiquitin-like-conjugating enzyme ATG3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP644123CHI CSB-EP644123CHI CSB-BP644123CHI CSB-MP644123CHI CSB-EP644123CHI-B |
Recombinant Chaetomium globosum Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP651941DPA CSB-EP651941DPA CSB-BP651941DPA CSB-MP651941DPA CSB-EP651941DPA-B |
Recombinant Aspergillus oryzae Autophagy-related protein 3(atg3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Dictyostelium discoideum (Slime mold)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP684782DKK CSB-EP684782DKK CSB-BP684782DKK CSB-MP684782DKK CSB-EP684782DKK-B |
Recombinant Dictyostelium discoideum Autophagy-related protein 3(atg3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP686302XBF CSB-EP686302XBF CSB-BP686302XBF CSB-MP686302XBF CSB-EP686302XBF-B |
Recombinant Xenopus tropicalis Ubiquitin-like-conjugating enzyme ATG3(atg3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP690414MPM CSB-EP690414MPM CSB-BP690414MPM CSB-MP690414MPM CSB-EP690414MPM-B |
Recombinant Magnaporthe oryzae Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP691417CZD CSB-EP691417CZD CSB-BP691417CZD CSB-MP691417CZD CSB-EP691417CZD-B |
Recombinant Candida albicans Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP706387NGS CSB-EP706387NGS CSB-BP706387NGS CSB-MP706387NGS CSB-EP706387NGS-B |
Recombinant Neosartorya fumigata Autophagy-related protein 3(atg3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP715472KBK CSB-EP715472KBK CSB-BP715472KBK CSB-MP715472KBK CSB-EP715472KBK-B |
Recombinant Kluyveromyces lactis Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Rattus norvegicus (Rat)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP718351RA CSB-EP718351RA CSB-BP718351RA CSB-MP718351RA CSB-EP718351RA-B |
Recombinant Rat Ubiquitin-like-conjugating enzyme ATG3(Atg3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP728203DIS CSB-EP728203DIS CSB-BP728203DIS CSB-MP728203DIS CSB-EP728203DIS-B |
Recombinant Debaryomyces hansenii Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP735039YAP CSB-EP735039YAP CSB-BP735039YAP CSB-MP735039YAP CSB-EP735039YAP-B |
Recombinant Yarrowia lipolytica Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP739742CZI CSB-EP739742CZI CSB-BP739742CZI CSB-MP739742CZI CSB-EP739742CZI-B |
Recombinant Candida glabrata Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Xenopus laevis (African clawed frog)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP740118XBE CSB-EP740118XBE CSB-BP740118XBE CSB-MP740118XBE CSB-EP740118XBE-B |
Recombinant Xenopus laevis Ubiquitin-like-conjugating enzyme ATG3(atg3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP761343DIL CSB-EP761343DIL CSB-BP761343DIL CSB-MP761343DIL CSB-EP761343DIL-B |
Recombinant Danio rerio Ubiquitin-like-conjugating enzyme ATG3(atg3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP765616DOT CSB-EP765616DOT CSB-BP765616DOT CSB-MP765616DOT CSB-EP765616DOT-B |
Recombinant Ashbya gossypii Autophagy-related protein 3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP863407MO CSB-EP863407MO CSB-BP863407MO CSB-MP863407MO CSB-EP863407MO-B |
Recombinant Mouse Ubiquitin-like-conjugating enzyme ATG3(Atg3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATG3 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP889107HU CSB-EP889107HU CSB-BP889107HU CSB-MP889107HU CSB-EP889107HU-B |
Recombinant Human Ubiquitin-like-conjugating enzyme ATG3(ATG3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP002288HU | Recombinant Human Ubiquitin-like-conjugating enzyme ATG3(ATG3) |
E.coli |
| CSB-YP002288HU CSB-BP002288HU CSB-MP002288HU CSB-EP002288HU-B |
Recombinant human Ubiquitin-like-conjugating enzyme ATG3 |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Ubiquitin-like-conjugating enzyme ATG3 is a protein in humans that is encoded by the ATG3 gene. The ATG3 protein is an E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2, or MAP1LC3A). The ATG12-ATG5 conjugate plays the role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and the cytoplasm to vacuole transport (Cvt). Its preferred substrate is MAP1LC3A. It also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, and ATG12 conjugation to ATG3 plays a role in mitochondrial homeostasis but not in autophagy.
