Name: Agr2 Antibody
Brand: CUSABIO
SKU: CSB-PA001458ZA01MO

Product Details

Full Product Name	Rabbit anti-Mus musculus (Mouse) Agr2 Polyclonal antibody
Uniprot No.	O88312
Target Names	Agr2
Alternative Names	Anterior gradient protein 2 homolog (AG-2) (mAG-2) (Protein Gob-4) (Secreted cement gland protein XAG-2 homolog), Agr2, Gob4
Raised in	Rabbit
Species Reactivity	Mus musculus
Immunogen	Recombinant Mus musculus Agr2 protein
Immunogen Species	Mus musculus (Mouse)
Conjugate	Non-conjugate
Clonality	Polyclonal
Isotype	IgG
Purification Method	Protein A/G
Concentration	It differs from different batches. Please contact us to confirm it.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form	Liquid
Tested Applications	ELISA, WB (ensure identification of antigen)
Protocols	ELISA Protocol
Troubleshooting and FAQs	Antibody FAQs
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables	① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control);
Quality Guarantee	① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive;
Lead Time	Made-to-order (12-14 weeks)

Target Background

Function (From Uniprot)	Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion.
Gene References into Functions	AGR2 accelerates skin wound healing through regulation of cell migration. PMID: 28665039 AGR2 induced in ER-stressed and inflammatory pre-neoplastic pancreas is a potential marker of cancer progenitor cells with an important functional role in PDAC initiation. PMID: 27941872 impact of AGR2 expression and EGFR signaling on tissue regeneration PMID: 27764193 EGFR-mediated signaling in NCI-H460 cells is disrupted with reduced AGR2 expression. PMID: 25666625 AGR2 has both intracellular and extracellular effects in the intestine PMID: 25111734 Results indicate that DNA methylation within the AGR2 promoter modulates more aggressive cancer cell phenotypes. PMID: 24920423 It was concluded that: the expression of AGR2 protein was significantly higher in asthmatic mice as compared with their normal counterparts; the expression was obviously related to the expression of Muc5ac protein and IL-13. PMID: 23392704 Agr2 consequently serves to maintain the balance between proliferating and differentiated epithelial cells. PMID: 23209296 Agr2 facilitates normal lobuloalveolar development by regulating mammary epithelial cell proliferation; we found no effects on apoptosis in Agr2(-/-) mammary epithelial cells. PMID: 22819674 Loss of Foxp1/4 in the developing lung and in postnatal secretory epithelium leads to ectopic activation of the goblet cell fate program, in part, through de-repression of the protein disulfide isomerase anterior gradient 2 (Agr2). PMID: 22675208 studies implicate Agr2 in intestinal homeostasis and ER stress and suggest a role in the etiology of inflammatory bowel disease PMID: 20025862 AGR2 may be important for the growth and development of the intestine as well as esophageal adenocarcinomas. PMID: 18199544 Overexpression of Agr2 is associated with asthma. PMID: 19028979 AGR2 is a unique member of the protein disulfide isomerase family, with a specialized and nonredundant role in intestinal mucus production PMID: 19359471 Show More Hide All
Subcellular Location	Secreted. Endoplasmic reticulum.
Protein Families	AGR family
Tissue Specificity	Expressed in lung, skeletal muscle, testis, liver, stomach, colon, small intestine, the goblet cells of the intestine and the mucuous neck cells of the stomach.
Database Links	KEGG: mmu:23795 STRING: 10090.ENSMUSP00000020898 UniGene: Mm.7244

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Agr2 Antibody

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